| The interleukin 1B-511 polymorphism is associated with the risk of developing restenosis after coronary stenting in Mexican patients. | |
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MedLine Citation:
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PMID: 18361937 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Inflammation is the primary response to vessel wall injury caused by stent placement in coronary arteries. Cytokines of the interleukin-1 family are central regulators in immunoinflammatory mechanisms. The objective of this study was to test for association between IL-1 family gene polymorphisms and risk for restenosis after coronary stent placement. The IL-1B-511, IL-1F10.3, RN.4T>C, RN.6/1C>T, RN.6/2C>G, and IL-1RN VNTR polymorphisms were analyzed by 5' exonuclease TaqMan genotyping assays and polymerase chain reaction in a group of 165 patients who underwent coronary artery stenting. Basal and procedure coronary angiography were analyzed in search of angiographic predictors of restenosis and follow-up angiography was analyzed in search of binary restenosis. Patients with IL-1B-511 TT genotype had a 1.89-fold increased risk of developing restenosis. The analysis considering the lesions treated demonstrated that the lesions of patients with IL-1B-511 TT genotype had a 3.44-fold increased risk of developing restenosis. When the analysis considered the type of stent, the risk of developing restenosis was increased in lesions of patients with TT genotype (odds ratio = 4.50) who underwent coronary bare-metal stent implantation. Multiple logistic analysis identified IL-1B-511 TT genotype as an independent predictor for restenosis. The results suggest that IL-1B-511 polymorphism could be involved in the risk of developing restenosis after coronary stent placement. |
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Authors:
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Emma Miranda-Malpica; Marco Antonio Martínez-Rios; José Manuel Fragoso; Hilda Delgadillo-Rodríguez; José Manuel Rodríguez-Pérez; Carlos González-Quesada; Nancy Martínez-Rodríguez; Arturo Saldaña-Mendoza; Marco Antonio Peña-Duque; Gilberto Vargas-Alarcón |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2008-01-22 |
Journal Detail:
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Title: Human immunology Volume: 69 ISSN: 0198-8859 ISO Abbreviation: Hum. Immunol. Publication Date: 2008 Feb |
Date Detail:
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Created Date: 2008-03-25 Completed Date: 2008-07-30 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8010936 Medline TA: Hum Immunol Country: United States |
Other Details:
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Languages: eng Pagination: 116-21 Citation Subset: IM |
Affiliation:
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Interventional Cardiology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Blood Vessel Prosthesis Implantation Coronary Angiography Coronary Restenosis / genetics* Female Genetic Predisposition to Disease Genotype Humans Interleukin 1 Receptor Antagonist Protein / genetics*, immunology* Interleukin-1beta / genetics* Male Mexico Middle Aged Polymorphism, Genetic Stents |
| Chemical | |
Reg. No./Substance:
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0/Interleukin 1 Receptor Antagonist Protein; 0/Interleukin-1beta |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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