Document Detail


The interleukin 1B-511 polymorphism is associated with the risk of developing restenosis after coronary stenting in Mexican patients.
MedLine Citation:
PMID:  18361937     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Inflammation is the primary response to vessel wall injury caused by stent placement in coronary arteries. Cytokines of the interleukin-1 family are central regulators in immunoinflammatory mechanisms. The objective of this study was to test for association between IL-1 family gene polymorphisms and risk for restenosis after coronary stent placement. The IL-1B-511, IL-1F10.3, RN.4T>C, RN.6/1C>T, RN.6/2C>G, and IL-1RN VNTR polymorphisms were analyzed by 5' exonuclease TaqMan genotyping assays and polymerase chain reaction in a group of 165 patients who underwent coronary artery stenting. Basal and procedure coronary angiography were analyzed in search of angiographic predictors of restenosis and follow-up angiography was analyzed in search of binary restenosis. Patients with IL-1B-511 TT genotype had a 1.89-fold increased risk of developing restenosis. The analysis considering the lesions treated demonstrated that the lesions of patients with IL-1B-511 TT genotype had a 3.44-fold increased risk of developing restenosis. When the analysis considered the type of stent, the risk of developing restenosis was increased in lesions of patients with TT genotype (odds ratio = 4.50) who underwent coronary bare-metal stent implantation. Multiple logistic analysis identified IL-1B-511 TT genotype as an independent predictor for restenosis. The results suggest that IL-1B-511 polymorphism could be involved in the risk of developing restenosis after coronary stent placement.
Authors:
Emma Miranda-Malpica; Marco Antonio Martínez-Rios; José Manuel Fragoso; Hilda Delgadillo-Rodríguez; José Manuel Rodríguez-Pérez; Carlos González-Quesada; Nancy Martínez-Rodríguez; Arturo Saldaña-Mendoza; Marco Antonio Peña-Duque; Gilberto Vargas-Alarcón
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-01-22
Journal Detail:
Title:  Human immunology     Volume:  69     ISSN:  0198-8859     ISO Abbreviation:  Hum. Immunol.     Publication Date:  2008 Feb 
Date Detail:
Created Date:  2008-03-25     Completed Date:  2008-07-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8010936     Medline TA:  Hum Immunol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  116-21     Citation Subset:  IM    
Affiliation:
Interventional Cardiology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico.
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MeSH Terms
Descriptor/Qualifier:
Aged
Blood Vessel Prosthesis Implantation
Coronary Angiography
Coronary Restenosis / genetics*
Female
Genetic Predisposition to Disease
Genotype
Humans
Interleukin 1 Receptor Antagonist Protein / genetics*,  immunology*
Interleukin-1beta / genetics*
Male
Mexico
Middle Aged
Polymorphism, Genetic
Stents
Chemical
Reg. No./Substance:
0/Interleukin 1 Receptor Antagonist Protein; 0/Interleukin-1beta

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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