Document Detail

Is interleukin-1 genotyping useful for the clinical management of patients with atrophic body gastritis?
MedLine Citation:
PMID:  18047563     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Atrophic body gastritis patients are at increased risk for gastric cancer. IL-1B/IL-1RN polymorphisms have been associated with gastric cancer susceptibility. The relationship between these polymorphisms and the long-term outcome of atrophic body gastritis patients is not known. AIM: To investigate whether the genotyping of IL-1B-511/IL-1RN polymorphisms is useful to characterize atrophic body gastritis patients at increased risk for gastric neoplasms. METHODS: IL-1B-511/IL-1RN polymorphisms were compared between 110 atrophic body gastritis patients and 110 age- and gender-matched controls, and patients were followed up (median 4.1 years) according to a cohort study design. RESULTS: Genotype frequencies of IL-1B-511/IL-1RN were similar between patients and controls. Atrophic body gastritis patients harbouring the wild type of IL-1B-511/IL-1RN polymorphisms were not different from those harbouring the proinflammatory pattern as far as regards gender, age, gastric cancer family history and metaplastic atrophy. Sixteen atrophic body gastritis patients developed a gastric neoplastic lesion at follow-up: eight were IL-1B-511-T carriers and eight were IL-1RN-allele-2 carriers. Harbouring the proinflammatory genotypes was not significantly associated with developing gastric neoplastic lesions. CONCLUSIONS: In atrophic body gastritis patients, IL-1B-511 and IL-1RN polymorphisms do not appear to be associated either with specific clinical, biochemical or histological features or with the development of gastric neoplastic lesions at long-term follow-up.
E Lahner; V D Corleto; G D'Ambra; E Di Giulio; G Delle Fave; B Annibale
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-11-28
Journal Detail:
Title:  Alimentary pharmacology & therapeutics     Volume:  27     ISSN:  1365-2036     ISO Abbreviation:  Aliment. Pharmacol. Ther.     Publication Date:  2008 Feb 
Date Detail:
Created Date:  2008-01-18     Completed Date:  2008-02-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8707234     Medline TA:  Aliment Pharmacol Ther     Country:  England    
Other Details:
Languages:  eng     Pagination:  355-65     Citation Subset:  IM    
Digestive and Liver Disease Unit, 2nd Medical School, University La Sapienza, Rome, Italy.
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MeSH Terms
Case-Control Studies
Cohort Studies
DNA / genetics
Follow-Up Studies
Gastritis, Atrophic / complications,  genetics*,  pathology,  therapy
Interleukin 1 Receptor Antagonist Protein / genetics*
Interleukin-1beta / genetics*
Middle Aged
Polymorphism, Genetic*
Stomach Neoplasms / etiology,  genetics*,  pathology
Reg. No./Substance:
0/IL1RN protein, human; 0/Interleukin 1 Receptor Antagonist Protein; 0/Interleukin-1beta; 9007-49-2/DNA

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