| Is interleukin-1 genotyping useful for the clinical management of patients with atrophic body gastritis? | |
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MedLine Citation:
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PMID: 18047563 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Atrophic body gastritis patients are at increased risk for gastric cancer. IL-1B/IL-1RN polymorphisms have been associated with gastric cancer susceptibility. The relationship between these polymorphisms and the long-term outcome of atrophic body gastritis patients is not known. AIM: To investigate whether the genotyping of IL-1B-511/IL-1RN polymorphisms is useful to characterize atrophic body gastritis patients at increased risk for gastric neoplasms. METHODS: IL-1B-511/IL-1RN polymorphisms were compared between 110 atrophic body gastritis patients and 110 age- and gender-matched controls, and patients were followed up (median 4.1 years) according to a cohort study design. RESULTS: Genotype frequencies of IL-1B-511/IL-1RN were similar between patients and controls. Atrophic body gastritis patients harbouring the wild type of IL-1B-511/IL-1RN polymorphisms were not different from those harbouring the proinflammatory pattern as far as regards gender, age, gastric cancer family history and metaplastic atrophy. Sixteen atrophic body gastritis patients developed a gastric neoplastic lesion at follow-up: eight were IL-1B-511-T carriers and eight were IL-1RN-allele-2 carriers. Harbouring the proinflammatory genotypes was not significantly associated with developing gastric neoplastic lesions. CONCLUSIONS: In atrophic body gastritis patients, IL-1B-511 and IL-1RN polymorphisms do not appear to be associated either with specific clinical, biochemical or histological features or with the development of gastric neoplastic lesions at long-term follow-up. |
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Authors:
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E Lahner; V D Corleto; G D'Ambra; E Di Giulio; G Delle Fave; B Annibale |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2007-11-28 |
Journal Detail:
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Title: Alimentary pharmacology & therapeutics Volume: 27 ISSN: 1365-2036 ISO Abbreviation: Aliment. Pharmacol. Ther. Publication Date: 2008 Feb |
Date Detail:
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Created Date: 2008-01-18 Completed Date: 2008-02-01 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8707234 Medline TA: Aliment Pharmacol Ther Country: England |
Other Details:
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Languages: eng Pagination: 355-65 Citation Subset: IM |
Affiliation:
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Digestive and Liver Disease Unit, 2nd Medical School, University La Sapienza, Rome, Italy. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Case-Control Studies Cohort Studies DNA / genetics Female Follow-Up Studies Gastritis, Atrophic / complications, genetics*, pathology, therapy Gastroscopy Genotype Humans Interleukin 1 Receptor Antagonist Protein / genetics* Interleukin-1beta / genetics* Male Middle Aged Polymorphism, Genetic* Stomach Neoplasms / etiology, genetics*, pathology |
| Chemical | |
Reg. No./Substance:
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0/IL1RN protein, human; 0/Interleukin 1 Receptor Antagonist Protein; 0/Interleukin-1beta; 9007-49-2/DNA |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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