| The interim 18-FDG-PET/CT failed to predict the outcome in diffuse large B-cell lymphoma patients treated at the diagnosis with rituximab-CHOP. | |
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MedLine Citation:
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PMID: 22234681 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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The role of Interim-PET in DLBCL is controversial. To determine predictive value of Interim-PET on PFS we enrolled 88 first-line DLBCL patients treated with 6-8 R-CHOP regardless of Interim-PET results. PET/CT were performed at diagnosis, after 2-4 courses and at the end of therapy with central reviewing according to visual dichotomous criteria. Results: Interim-PET 72% negative, 28% positive; Final-PET 88% negative, 12% positive; clinical complete response 90%. Concordance between clinical response and Final-PET negativity was 97% due to two false positive. With a median follow-up of 26.2 months, 2-year OS and PFS were 91% and 77%. 2-year PFS rates for Interim-PET and Final-PET negative vs. positive were: I-PET 85% vs. 72% (p.0475); F-PET 83% vs. 64% (p<.001). Due to a small number of events, two independent bivariate Cox-models were tested for PFS. In model one Final-PET contradicted Interim-PET (HR 5.03, 95%CI 1.37-18.43, p=.015 vs. 1.27, 95%CI 0.40-4.03, p=.691); in model two, Final-PET (HR 4.54, 95% CI 1.68-12.31) and IPI score (HR 5.36, 95% CI 1.91-15.05, p=.001) remained independent prognostic factors. In conclusion, positive interim-PET is not predictive of a worse outcome in DLBCL patients treated with R-CHOP. Larger prospective studies and harmonization of Interim-PET reading criteria are needed in DLBCL. |
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Authors:
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Patrizia Pregno; Annalisa Chiappella; Marilena Bellò; Barbara Botto; Simone Ferrero; Silvia Franceschetti; Francesca Giunta; Marco Ladetto; Giorgio Limerutti; Massimo Menga; Maura Nicolosi; Giorgio Priolo; Benedetta Puccini; Luigi Rigacci; Flavia Salvi; Luca Vaggelli; Roberto Passera; Gianni Bisi; Umberto Vitolo |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-1-10 |
Journal Detail:
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Title: Blood Volume: - ISSN: 1528-0020 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-1-11 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7603509 Medline TA: Blood Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Hematology 2, San Giovanni Battista Hospital and University, Turin, Italy; |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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