Document Detail

An interesting presentation of intrathoracic extramedullary hematopoiesis in a patient with thalassemia intermedia.
MedLine Citation:
PMID:  14641147     Owner:  NLM     Status:  MEDLINE    
Extramedullary hematopoiesis (EMH) occurs as a compensatory mechanism for bone marrow dysfunction in severe thalassemia. In addition to the more common locations, such as liver, spleen and lymph nodes, a mass of EMH may occasionally occur in the thorax. Intrathoracic EMH is usually asymptomatic. A 69-year-old woman who initially presented with hematuria, dysuria, and left inguinal pain was found to have paravertebral masses in the thorax. Histopathologic examination of a CT-guided needle aspiration biopsy of the masses showed the presence of trilineage hematopoiesis. We present this unusual case, in which EMH was diagnosed by chance in an elderly patient with no symptoms related to thalassemia.
B Turgut; G E Pamuk; O Vural; M Demir; E Unlü; H Celik; B Cakir; K Kutlu
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Clinical and laboratory haematology     Volume:  25     ISSN:  0141-9854     ISO Abbreviation:  Clin Lab Haematol     Publication Date:  2003 Dec 
Date Detail:
Created Date:  2003-12-03     Completed Date:  2004-09-09     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7907061     Medline TA:  Clin Lab Haematol     Country:  England    
Other Details:
Languages:  eng     Pagination:  409-12     Citation Subset:  IM    
Department of Hematology, Trakya Medical Faculty, University of Trakya, Edirne, Turkey.
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MeSH Terms
Biopsy, Needle
Cell Lineage
Hematopoiesis, Extramedullary*
Hematuria / etiology
Hepatomegaly / etiology
Incidental Findings
Mediastinum / pathology,  radiography,  radionuclide imaging
Radiography, Interventional
Radiopharmaceuticals / diagnostic use
Splenomegaly / etiology
Technetium Tc 99m Sulfur Colloid / diagnostic use
Tomography, Emission-Computed, Single-Photon
Tomography, X-Ray Computed
beta-Thalassemia / complications,  physiopathology*,  radiography,  radionuclide imaging
Reg. No./Substance:
0/Radiopharmaceuticals; 0/Technetium Tc 99m Sulfur Colloid

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