Document Detail


The interactive effects of alcohol and cocaine on maternal and fetal toxicity in the Long-Evans rat.
MedLine Citation:
PMID:  3226379     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The number of obstetric patients with polydrug abuse problems has increased substantially in recent years. One of the most common drug combinations is alcohol and cocaine. The effect of this drug combination on pregnancy is, therefore, of interest. Consequently, the present study investigated the relative and interactive effects of these two drugs on pregnancy outcome in an animal model. Alcohol and cocaine were administered, both separately and in combination, to separate groups of pregnant Long-Evans rats from gestation day 7-19. Animals were then sacrificed and examined on gestation day 20. Control animals were given vehicle only or were nontreated. The isobolographic method was used to evaluate the effects of the alcohol-by-cocaine interaction on select maternal and fetal variables. This method of analysis indicated that alcohol and cocaine had interactive effects that were linearly additive for some variables and infraadditive for others. In general, the results suggest that the alcohol-plus-cocaine drug combination poses a greater risk to pregnancy than either drug alone.
Authors:
M W Church; B A Dintcheff; P K Gessner
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Neurotoxicology and teratology     Volume:  10     ISSN:  0892-0362     ISO Abbreviation:  Neurotoxicol Teratol     Publication Date:    1988 Jul-Aug
Date Detail:
Created Date:  1989-03-29     Completed Date:  1989-03-29     Revised Date:  2009-10-26    
Medline Journal Info:
Nlm Unique ID:  8709538     Medline TA:  Neurotoxicol Teratol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  355-61     Citation Subset:  IM    
Affiliation:
Department of Obstetrics/Gynecology, School of Medicine, Wayne State University, Detroit, MI.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cocaine / toxicity*
Drinking Behavior / drug effects
Drug Interactions
Ethanol / toxicity*
Feeding Behavior / drug effects
Female
Fetus / drug effects*
Gestational Age
Lethal Dose 50
Pregnancy
Rats
Grant Support
ID/Acronym/Agency:
DA05536/DA/NIDA NIH HHS; S07 05938-02//PHS HHS
Chemical
Reg. No./Substance:
50-36-2/Cocaine; 64-17-5/Ethanol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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