| An interactive computer program for randomization analysis of response curves with facilities for multiple comparisons. | |
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MedLine Citation:
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PMID: 1582188 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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An interactive Fortran program, MUCRA, is presented. The program can perform randomization analysis of a completely randomized or randomized-blocks design extended to growth and response curves. A single-step Scheffé-type procedure as well as the Peritz's closed step-down procedure have been implemented which control the familywise type I error-rate. In general, MUCRA is suitable as a computer tool for a distribution-free analysis of variance with repeated measures. The use of MUCRA is demonstrated by analyzing the effects oxprenolol and atenolol have on exercise heart rate. Oxprenolol is a non-selective beta-blocker with moderate intrinsic sympathomimetic activity (ISA), given by the Oros delivery system. Atenolol is a beta 1-selective blocker without ISA. A randomized placebo-controlled crossover design was used to compare the effects of the beta 1-blockers on heart rate during a progressive maximal exercise test on a bicycle ergometer. Application of the Scheffé-type procedure showed that the two drugs significantly (alpha = .05) reduce the heart rate during the exercise test at the three prechosen times (2, 5, and 24 hr) after intake. The reduction from atenolol is more pronounced than from oxprenolol Oros at 2 and 5 hr. |
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Authors:
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E S Tan; J M Roos; A Volovics; M A Van Baak; R J Does |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Computers and biomedical research, an international journal Volume: 25 ISSN: 0010-4809 ISO Abbreviation: Comput. Biomed. Res. Publication Date: 1992 Apr |
Date Detail:
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Created Date: 1992-06-12 Completed Date: 1992-06-12 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0100331 Medline TA: Comput Biomed Res Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 101-16 Citation Subset: IM |
Affiliation:
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Department of Medical Informatics and Statistics, University of Limburg, Maastricht, The Netherlands. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Atenolol / pharmacology Exercise / physiology Female Heart Rate / drug effects Humans Male Oxprenolol / pharmacology Random Allocation* Software* Software Design |
| Chemical | |
Reg. No./Substance:
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29122-68-7/Atenolol; 6452-71-7/Oxprenolol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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