Document Detail


An interactive computer program for randomization analysis of response curves with facilities for multiple comparisons.
MedLine Citation:
PMID:  1582188     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
An interactive Fortran program, MUCRA, is presented. The program can perform randomization analysis of a completely randomized or randomized-blocks design extended to growth and response curves. A single-step Scheffé-type procedure as well as the Peritz's closed step-down procedure have been implemented which control the familywise type I error-rate. In general, MUCRA is suitable as a computer tool for a distribution-free analysis of variance with repeated measures. The use of MUCRA is demonstrated by analyzing the effects oxprenolol and atenolol have on exercise heart rate. Oxprenolol is a non-selective beta-blocker with moderate intrinsic sympathomimetic activity (ISA), given by the Oros delivery system. Atenolol is a beta 1-selective blocker without ISA. A randomized placebo-controlled crossover design was used to compare the effects of the beta 1-blockers on heart rate during a progressive maximal exercise test on a bicycle ergometer. Application of the Scheffé-type procedure showed that the two drugs significantly (alpha = .05) reduce the heart rate during the exercise test at the three prechosen times (2, 5, and 24 hr) after intake. The reduction from atenolol is more pronounced than from oxprenolol Oros at 2 and 5 hr.
Authors:
E S Tan; J M Roos; A Volovics; M A Van Baak; R J Does
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Computers and biomedical research, an international journal     Volume:  25     ISSN:  0010-4809     ISO Abbreviation:  Comput. Biomed. Res.     Publication Date:  1992 Apr 
Date Detail:
Created Date:  1992-06-12     Completed Date:  1992-06-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0100331     Medline TA:  Comput Biomed Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  101-16     Citation Subset:  IM    
Affiliation:
Department of Medical Informatics and Statistics, University of Limburg, Maastricht, The Netherlands.
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MeSH Terms
Descriptor/Qualifier:
Adult
Atenolol / pharmacology
Exercise / physiology
Female
Heart Rate / drug effects
Humans
Male
Oxprenolol / pharmacology
Random Allocation*
Software*
Software Design
Chemical
Reg. No./Substance:
29122-68-7/Atenolol; 6452-71-7/Oxprenolol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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