Document Detail

The interactions of oxidative stress and inflammation with vascular dysfunction in ageing: the vascular health triad.
MedLine Citation:
PMID:  22453933     Owner:  NLM     Status:  MEDLINE    
Oxidative stress and inflammation are increased with advancing age. Evidence suggests that oxidative stress and inflammation both lead to impaired vascular function. There is also evidence to suggest that inflammation may cause an increase in radical production leading to enhanced oxidative stress. In addition, oxidative stress may cause an increase in inflammation; however, the interactions between these factors are not fully understood. In this review, we propose the vascular health triad, which draws associations and interactions between oxidative stress and inflammation seen in ageing, and the consequences for vascular function. We review evidence suggesting that exercise may ameliorate the age-related decline in vascular function, through reductions in both oxidative stress and inflammation.
Alex J Wadley; Jet J C S Veldhuijzen van Zanten; Sarah Aldred
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Publication Detail:
Type:  Journal Article; Review     Date:  2012-03-28
Journal Detail:
Title:  Age (Dordrecht, Netherlands)     Volume:  35     ISSN:  1574-4647     ISO Abbreviation:  Age (Dordr)     Publication Date:  2013 Jun 
Date Detail:
Created Date:  2013-04-26     Completed Date:  2013-10-17     Revised Date:  2014-06-03    
Medline Journal Info:
Nlm Unique ID:  101250497     Medline TA:  Age (Dordr)     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  705-18     Citation Subset:  IM    
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MeSH Terms
Aging / physiology*
Blood Vessels* / metabolism,  pathology,  physiopathology
Cardiovascular Diseases* / metabolism,  pathology,  physiopathology
Endothelium, Vascular / metabolism,  pathology,  physiopathology
Inflammation* / metabolism,  pathology,  physiopathology
Oxidative Stress / physiology*
Reactive Oxygen Species / metabolism
Risk Factors
Reg. No./Substance:
0/Reactive Oxygen Species

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