| Prolactin/Leptin interactions in the control of food intake in rats. | |
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MedLine Citation:
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PMID: 17872372 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Recent evidence suggests that the peptide hormone prolactin (PRL) modulates energy balance through a number of mechanisms, including acting in the brain to increase food intake. In the current studies, we first demonstrated that chronic infusions of PRL into the lateral ventricles increased food intake in cycling rats without disrupting estrous cyclicity. In subsequent experiments the hypothesis that at least part of PRL's ability to increase food intake resulted from PRL-induced leptin resistance was tested. Female rats given chronic infusions of PRL (5 microg/h) into the cerebral ventricles for 10 d did not show a reduction in food intake or body weight after a central injection of 4 microg murine leptin, whereas the expected reduction in both of these parameters was seen in vehicle-infused rats. Leptin injections were without effect on these parameters, whether they were administered to free feeding PRL-infused rats or after 24-h food deprivation. This lack of a behavioral response to leptin was accompanied by an attenuation in Fos induction and phosphorylation of signal transducer and activator of transcription 3 after leptin administration in PRL-infused rats in both the ventromedial hypothalamus and paraventricular hypothalamic nucleus. |
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Authors:
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Lindsay Naef; Barbara Woodside |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2007-09-13 |
Journal Detail:
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Title: Endocrinology Volume: 148 ISSN: 0013-7227 ISO Abbreviation: Endocrinology Publication Date: 2007 Dec |
Date Detail:
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Created Date: 2007-11-16 Completed Date: 2008-06-17 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0375040 Medline TA: Endocrinology Country: United States |
Other Details:
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Languages: eng Pagination: 5977-83 Citation Subset: AIM; IM |
Affiliation:
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Center for Studies in Behavioral Neurobiology, Concordia University, 7141 Sherbrooke Street West, Montreal, Quebec, Canada. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Body Weight / drug effects Brain / drug effects, metabolism Dose-Response Relationship, Drug Drug Interactions Eating / drug effects* Female Immunohistochemistry Leptin / administration & dosage, blood, pharmacology* Prolactin / administration & dosage, pharmacology* Rats Rats, Wistar STAT3 Transcription Factor / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Leptin; 0/STAT3 Transcription Factor; 0/Stat3 protein, mouse; 9002-62-4/Prolactin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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