Document Detail

Prolactin/Leptin interactions in the control of food intake in rats.
MedLine Citation:
PMID:  17872372     Owner:  NLM     Status:  MEDLINE    
Recent evidence suggests that the peptide hormone prolactin (PRL) modulates energy balance through a number of mechanisms, including acting in the brain to increase food intake. In the current studies, we first demonstrated that chronic infusions of PRL into the lateral ventricles increased food intake in cycling rats without disrupting estrous cyclicity. In subsequent experiments the hypothesis that at least part of PRL's ability to increase food intake resulted from PRL-induced leptin resistance was tested. Female rats given chronic infusions of PRL (5 microg/h) into the cerebral ventricles for 10 d did not show a reduction in food intake or body weight after a central injection of 4 microg murine leptin, whereas the expected reduction in both of these parameters was seen in vehicle-infused rats. Leptin injections were without effect on these parameters, whether they were administered to free feeding PRL-infused rats or after 24-h food deprivation. This lack of a behavioral response to leptin was accompanied by an attenuation in Fos induction and phosphorylation of signal transducer and activator of transcription 3 after leptin administration in PRL-infused rats in both the ventromedial hypothalamus and paraventricular hypothalamic nucleus.
Lindsay Naef; Barbara Woodside
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-09-13
Journal Detail:
Title:  Endocrinology     Volume:  148     ISSN:  0013-7227     ISO Abbreviation:  Endocrinology     Publication Date:  2007 Dec 
Date Detail:
Created Date:  2007-11-16     Completed Date:  2008-06-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0375040     Medline TA:  Endocrinology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  5977-83     Citation Subset:  AIM; IM    
Center for Studies in Behavioral Neurobiology, Concordia University, 7141 Sherbrooke Street West, Montreal, Quebec, Canada.
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MeSH Terms
Body Weight / drug effects
Brain / drug effects,  metabolism
Dose-Response Relationship, Drug
Drug Interactions
Eating / drug effects*
Leptin / administration & dosage,  blood,  pharmacology*
Prolactin / administration & dosage,  pharmacology*
Rats, Wistar
STAT3 Transcription Factor / metabolism
Reg. No./Substance:
0/Leptin; 0/STAT3 Transcription Factor; 0/Stat3 protein, mouse; 9002-62-4/Prolactin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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