| Host/parasite interactions in bacterial endophthalmitis. | |
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MedLine Citation:
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PMID: 9084109 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Bacterial infections within the eye arise as complications of intraocular surgery, penetrating injury, or hematogenous spread from distant anatomical sites. Because: 1) the interior surfaces of the eye are lined with sensitive, nonregenerating tissues, 2) the inner chambers of the eye are relatively sequestered from circulating immunological components, 3) the integrity of blood-ocular barriers provides poor penetration of systemically administered antibiotics, and 4) aqueous and vitreous humor represent rich, relatively acellular culture media; endophthalmitis often progresses rapidly and total loss of vision frequently results. Years of clinical experience have shown that current therapies for endophthalmitis, including antimicrobials, antiinflammatory agents, and vitrectomy, are frequently unsuccessful in ameliorating destruction of intraocular tissues. While bacterial and host factors were thought to play key roles in the course and severity of endophthalmitis, it is only recently that their contributions have been experimentally defined. Molecular-based techniques are gaining increased use in the study of infectious eye diseases. Current findings regarding the host/parasite interactions within the eye are reviewed, and a resulting integrative model of the natural course of endophthalmitis proposed. A molecular-level understanding of the roles of both bacterial and host factors during endophthalmitis will likely reveal potential targets for therapeutic intervention aimed at salvaging vision. |
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Authors:
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B D Jett; D W Parke; M C Booth; M S Gilmore |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review |
Journal Detail:
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Title: Zentralblatt für Bakteriologie : international journal of medical microbiology Volume: 285 ISSN: 0934-8840 ISO Abbreviation: Zentralbl. Bakteriol. Publication Date: 1997 Feb |
Date Detail:
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Created Date: 1997-06-12 Completed Date: 1997-06-12 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9203851 Medline TA: Zentralbl Bakteriol Country: GERMANY |
Other Details:
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Languages: eng Pagination: 341-67 Citation Subset: IM |
Affiliation:
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Department of Ophthalmology, University of Oklahoma Health Sciences Center, Dean A. McGee Eye Institute, Oklahoma City, USA. brad-jett@nokhsc.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Bacterial Capsules
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adverse effects Bacterial Infections / microbiology*, therapy Bacterial Toxins / adverse effects Endophthalmitis / microbiology*, therapy Host-Parasite Interactions* Humans Models, Biological |
| Grant Support | |
ID/Acronym/Agency:
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EY08289/EY/NEI NIH HHS; EY10867/EY/NEI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Bacterial Capsules; 0/Bacterial Toxins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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