| The interactions between iophenoxic acid, iopanoic acid, bilirubin and human serum albumin as studied by fluorescence and Sephadex gel filtration. | |
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MedLine Citation:
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PMID: 963887 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Iophenoxic acid increases the fluorescence of bilirubin bound to human serum albumin at drug/albumin molar ratios lower than 1, while iopanoic acid decreases it. The fluorescence enhancement results probably from a change in the fluorescence efficiency due to an iophenoxic acid-induced conformational change in the albumin, which in turn causes displacement of bilirubin from the protein. Iophenoxic acid does not affect the high-affinity bilirubin binding site of albumin. Therefore any enhancement in bilirubin fluorescence caused by the drug indicates that bilirubin is bound to the low-affinity binding sites of albumin. The use of iophenoxic acid in the determination of the extent of saturation of the high-affinity bilirubin binding site of albumin may be of value in the clinical management of infants with neonatal jaundice. |
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Authors:
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D J Birkett; J Kapitulnik |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Clinica chimica acta; international journal of clinical chemistry Volume: 71 ISSN: 0009-8981 ISO Abbreviation: Clin. Chim. Acta Publication Date: 1976 Sep |
Date Detail:
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Created Date: 1976-12-01 Completed Date: 1976-12-01 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 1302422 Medline TA: Clin Chim Acta Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 129-35 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Bilirubin* Chromatography, Gel Cinnamates Humans Iodobenzenes* Iopanoic Acid* / analogs & derivatives* Protein Binding Serum Albumin* Spectrometry, Fluorescence |
| Chemical | |
Reg. No./Substance:
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0/Cinnamates; 0/Iodobenzenes; 0/Serum Albumin; 635-65-4/Bilirubin; 96-83-3/Iopanoic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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