Document Detail


The interaction with PDGF as a source of G1 phase heterogeneity in normal mouse fibroblasts.
MedLine Citation:
PMID:  2425987     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In normal mouse fibroblasts exponentially growing at suboptimal serum concentration the population of cells having a presynthetic (G1) DNA content is heterogeneous, since there are present both competent and non-competent cells (Sturani et al, 1984). We show here that SV40 transformed 3T3 fibroblasts, which have lost growth control and serum requirement, lack the G1 non-competent phase. These findings are confirmed by the different kinetics of exit from the G1 compartment of transformed and normal cells. In addition a positive correlation is reported between the fraction of non-competent cells and the average abundance of the phosphorylable PDGF receptor on the cell surface of normal cells.
Authors:
L Toschi; R Zippel; E Martegani; E Sturani
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Cell biology international reports     Volume:  10     ISSN:  0309-1651     ISO Abbreviation:  Cell Biol. Int. Rep.     Publication Date:  1986 Jul 
Date Detail:
Created Date:  1986-09-23     Completed Date:  1986-09-23     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  7708050     Medline TA:  Cell Biol Int Rep     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  575-82     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Cycle / drug effects*
Cell Transformation, Viral
Culture Media
Fibroblasts / cytology*
Interphase
Mice
Phosphorylation
Phosphotyrosine
Platelet-Derived Growth Factor / pharmacology*
Receptors, Cell Surface / physiology*
Receptors, Platelet-Derived Growth Factor
Simian virus 40
Tyrosine / analogs & derivatives,  metabolism
Chemical
Reg. No./Substance:
0/Culture Media; 0/Platelet-Derived Growth Factor; 0/Receptors, Cell Surface; 21820-51-9/Phosphotyrosine; 55520-40-6/Tyrosine; EC 2.7.10.1/Receptors, Platelet-Derived Growth Factor

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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