Document Detail


The interaction of tumor localizing porphyrins with collagen and elastin.
MedLine Citation:
PMID:  7100629     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The interaction of a series of tumor localizing porphyrins with collagen and elastin was determined. All the porphyrins studied bound to both acid soluble and insoluble collagen, but to differing extents, as well as to elastin. The extent of binding to acid soluble collagen was greater than that to insoluble collagen. The major consequence of this association was a marked decrease in the solubility of the acid soluble collagen suggesting stabilization of the fibrillar structure of the collagen had occurred. Evidence was also obtained indicating the porphyrins could bind to collagen alpha-chains. The relevance of these findings to porphyrin localization is discussed.
Authors:
D A Musser; J M Wagner; M Datta-Gupta
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Research communications in chemical pathology and pharmacology     Volume:  36     ISSN:  0034-5164     ISO Abbreviation:  Res. Commun. Chem. Pathol. Pharmacol.     Publication Date:  1982 May 
Date Detail:
Created Date:  1982-09-24     Completed Date:  1982-09-24     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0244734     Medline TA:  Res Commun Chem Pathol Pharmacol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  251-9     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Chemical Phenomena
Chemistry
Collagen / metabolism*
Elastin / metabolism*
Humans
Neoplasms / metabolism*
Porphyrins / metabolism*
Protein Binding
Solubility
Chemical
Reg. No./Substance:
0/Porphyrins; 14609-54-2/tetracarboxyphenylporphine; 35218-75-8/tetraphenylporphine sulfonate; 9007-34-5/Collagen; 9007-58-3/Elastin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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