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The interaction of mycoplasmas with mammalian cells. I. HeLa cells, neutrophils, and eosinophils.
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MedLine Citation:
PMID:  5922745     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The ultrastructure of three mycoplasma species, Mycoplasma pneumoniae, Mycoplasma gallisepticum, and Mycoplasma neurolyticum, has been studied in isolated form as well as in HeLa cell cultures and following incubation with human peripheral blood leukocytes. During log growth phase, the organisms could be distinguished from each other on the basis of their fine structure. In mammalian cell cultures, PPLO's appeared to proliferate on the plasma membranes which had markedly increased their surface area by means of long cytoplasmic processes which extended toward and surrounded them. Some of the microorganisms affected in this way may well have lain, not in vacuoles, but at the bottom of crypts. It is suggested that the cytopathogenic effect exerted by PPLO's on some tissue cultures may be attributable to membrane damage. Mycoplasmas adhered to leukocyte plasma membranes in a similar manner. They were avidly phagocytosed by neutrophils and eosinophils with accompanying degranulation of the white cells. It is thus likely that the local inflammatory reaction induced by PPLO's does not differ in essence from that caused by bacteria.
Authors:
D Zucker-Franklin; M Davidson; L Thomas
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of experimental medicine     Volume:  124     ISSN:  0022-1007     ISO Abbreviation:  J. Exp. Med.     Publication Date:  1966 Sep 
Date Detail:
Created Date:  1967-01-23     Completed Date:  1967-01-23     Revised Date:  2010-09-10    
Medline Journal Info:
Nlm Unique ID:  2985109R     Medline TA:  J Exp Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  521-32     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Culture Techniques*
Eosinophils / cytology*
Hela Cells
Humans
Microscopy, Electron
Mycoplasma / cytology*
Neutrophils / cytology*
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Full Text
Journal Information
Journal ID (nlm-ta): J Exp Med
ISSN: 0022-1007
ISSN: 1540-9538
Publisher: The Rockefeller University Press
Article Information
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Copyright © 1966 by The Rockefeller University Press
Received Day: 16 Month: 3 Year: 1966
Print publication date: Day: 1 Month: 9 Year: 1966
Volume: 124 Issue: 3
First Page: 521 Last Page: 532
ID: 2138233
PubMed Id: 5922745

THE INTERACTION OF MYCOPLASMAS WITH MAMMALIAN CELLS : I. HELA CELLS, NEUTROPHILS, AND EOSINOPHILS
Dorothea Zucker-Franklin
Morton Davidson
Lewis Thomas
From the Department of Medicine and Rheumatic Diseases Study Group, New York University School of Medicine, New York


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