Document Detail


The interaction of mannose binding lectin (MBL) with mannose containing glycopeptides and the resultant potential impact on invasive fungal infection.
MedLine Citation:
PMID:  19180724     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Mannnose-binding lectin (MBL) binds oligosaccharides on the surface of microorganisms to form complexes that activate the complement cascade and facilitate phagocytosis. Teicoplanin and dalbavancin glycopeptide antibiotics possess N-acetyl glucosamine and mannose oligosaccharides that may bind MBL. Pharmaceuticals capable of binding to MBL may decrease clearance of significant pathogens such as yeast. An invasive candidemia murine model was utilized to evaluate differences in survival between mannose- and teicoplanin-treated groups compared to a control group administered normal saline. Three groups of BALB/c mice were injected with Candida albicans ATCC 44858 (1.4 x 10(6) CFU). Pharmaceutical agents were administered 2 h pre-infection and 8 h post-infection. In vivo cumulative survival at 52 h revealed 10%, 30% and 90% survival rates for mice administered mannose, teicoplanin, and saline, respectively. There was 0% survival for mice given mannose or teicoplanin at 56 h, compared with 70% for the normal saline treated mice at the same time point (P < 0.05). This in vivo study shows 'accelerated progression of infection' for Candida-inoculated mice exposed to mannose or teicoplanin compared to those given normal saline. Further, protein polyacrylamide gel electrophoresis studies suggested a potential MBL-drug interaction which may attenuate complement activation, opsonization and phagocytosis.
Authors:
Patricia I Sealy; Bianca Garner; Ed Swiatlo; Stanley W Chapman; John D Cleary
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Medical mycology     Volume:  46     ISSN:  1369-3786     ISO Abbreviation:  Med. Mycol.     Publication Date:  2008 Sep 
Date Detail:
Created Date:  2009-01-30     Completed Date:  2009-02-19     Revised Date:  2013-12-13    
Medline Journal Info:
Nlm Unique ID:  9815835     Medline TA:  Med Mycol     Country:  England    
Other Details:
Languages:  eng     Pagination:  531-9     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Anti-Bacterial Agents / administration & dosage*,  chemistry,  metabolism
Candida albicans / immunology*,  metabolism
Candidiasis / immunology*,  microbiology,  mortality
Host-Pathogen Interactions
Humans
Mannose / administration & dosage*,  metabolism
Mannose-Binding Lectin / immunology*,  metabolism
Mice
Mice, Inbred BALB C
Protein Binding
Survival
Teicoplanin / administration & dosage*,  chemistry,  metabolism
Chemical
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Mannose-Binding Lectin; 61036-62-2/Teicoplanin; PHA4727WTP/Mannose

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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