| The interaction of mannose binding lectin (MBL) with mannose containing glycopeptides and the resultant potential impact on invasive fungal infection. | |
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MedLine Citation:
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PMID: 19180724 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Mannnose-binding lectin (MBL) binds oligosaccharides on the surface of microorganisms to form complexes that activate the complement cascade and facilitate phagocytosis. Teicoplanin and dalbavancin glycopeptide antibiotics possess N-acetyl glucosamine and mannose oligosaccharides that may bind MBL. Pharmaceuticals capable of binding to MBL may decrease clearance of significant pathogens such as yeast. An invasive candidemia murine model was utilized to evaluate differences in survival between mannose- and teicoplanin-treated groups compared to a control group administered normal saline. Three groups of BALB/c mice were injected with Candida albicans ATCC 44858 (1.4 x 10(6) CFU). Pharmaceutical agents were administered 2 h pre-infection and 8 h post-infection. In vivo cumulative survival at 52 h revealed 10%, 30% and 90% survival rates for mice administered mannose, teicoplanin, and saline, respectively. There was 0% survival for mice given mannose or teicoplanin at 56 h, compared with 70% for the normal saline treated mice at the same time point (P < 0.05). This in vivo study shows 'accelerated progression of infection' for Candida-inoculated mice exposed to mannose or teicoplanin compared to those given normal saline. Further, protein polyacrylamide gel electrophoresis studies suggested a potential MBL-drug interaction which may attenuate complement activation, opsonization and phagocytosis. |
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Authors:
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Patricia I Sealy; Bianca Garner; Ed Swiatlo; Stanley W Chapman; John D Cleary |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Medical mycology : official publication of the International Society for Human and Animal Mycology Volume: 46 ISSN: 1369-3786 ISO Abbreviation: Med. Mycol. Publication Date: 2008 Sep |
Date Detail:
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Created Date: 2009-01-30 Completed Date: 2009-02-19 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9815835 Medline TA: Med Mycol Country: England |
Other Details:
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Languages: eng Pagination: 531-9 Citation Subset: IM |
Affiliation:
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University of Mississippi Medical Center, Jackson, MS 39216-4505, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anti-Bacterial Agents / administration & dosage*, chemistry, metabolism Candida albicans / immunology*, metabolism Candidiasis / immunology*, microbiology, mortality Host-Pathogen Interactions Humans Mannose / administration & dosage*, metabolism Mannose-Binding Lectin / immunology*, metabolism Mice Mice, Inbred BALB C Protein Binding Survival Teicoplanin / administration & dosage*, chemistry, metabolism |
| Chemical | |
Reg. No./Substance:
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0/Anti-Bacterial Agents; 0/Mannose-Binding Lectin; 31103-86-3/Mannose; 61036-62-2/Teicoplanin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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