| The interaction of mPar3 with the ubiquitin ligase Smurf2 is required for the establishment of neuronal polarity. | |
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MedLine Citation:
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PMID: 17906294 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The Par polarity complex consisting of the evolutionarily conserved proteins mPar3, mPar6, and aPKC regulates cell polarity in many cell types including neurons. Here we show that mPar3 is required for the establishment of neuronal polarity and links the Smurf2 to Kinesin-2. The HECT domain E3 ubiquitin ligase Smurf2 ensures that neurons extend only a single axon by initiating the degradation of inactive Rap1B through the ubiquitin/proteasome system. Its interaction with mPar3 is required to localize Smurf2 to growth cones and restrict Rap1B to the axon. Interfering with the binding of mPar3 to Kinesin-2 or Smurf2 to mPar3 and knockdown of mPar3 by RNAi disrupt the establishment of neuronal polarity through the failure to restrict Rap1B to a single neurite. |
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Authors:
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Jens C Schwamborn; Mohammad R Khazaei; Andreas W Püschel |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2007-09-28 |
Journal Detail:
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Title: The Journal of biological chemistry Volume: 282 ISSN: 0021-9258 ISO Abbreviation: J. Biol. Chem. Publication Date: 2007 Nov |
Date Detail:
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Created Date: 2007-11-26 Completed Date: 2008-02-04 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 2985121R Medline TA: J Biol Chem Country: United States |
Other Details:
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Languages: eng Pagination: 35259-68 Citation Subset: IM |
Affiliation:
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Abteilung Molekularbiologie, Institut für Allgemeine Zoologie und Genetik, Westfälische Wilhelms-Universität Münster, Schlossplatz 5, D-48149 Münster, Germany. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Body Patterning Carrier Proteins / metabolism* Gene Expression Regulation* Gene Expression Regulation, Developmental* Hippocampus / metabolism Humans Kinesin / metabolism* Models, Biological Neurons / metabolism Protein Binding Protein Structure, Tertiary RNA Interference Rats Ubiquitin-Protein Ligases / biosynthesis*, chemistry, physiology* rap GTP-Binding Proteins / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Carrier Proteins; 0/Kif3a protein, rat; 0/PAR-3 protein, rat; EC 3.6.1.-/Kinesin; EC 3.6.1.-/Rap1b protein, rat; EC 3.6.5.2/rap GTP-Binding Proteins; EC 6.3.2.19/Smurf2 protein, rat; EC 6.3.2.19/Ubiquitin-Protein Ligases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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