| An interaction between DAT1 and having an alcoholic father predicts serious alcohol problems in a sample of males. | |
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MedLine Citation:
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PMID: 19443134 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The current study examines whether the dopamine transporter (DAT1) VNTR polymorphism and paternal alcoholism are related to serious alcohol problems. Using data from the National Longitudinal Study of Adolescent Health (Add Health), we found that the DAT1 polymorphism interacted with paternal alcoholism to predict serious alcohol problems among males. Specifically, the 10-repeat allele conferred an increase of alcohol problems only among males who also had an alcoholic father; the 10-repeat allele was unrelated to alcohol problems for males without an alcoholic father. Coefficient tests revealed that this interaction effect was stronger among African-American males. Females who possessed the 9-repeat allele were more likely to report serious alcohol problems, but this effect was not moderated by paternal alcoholism. These analyses suggest that additive and interactive effects of DAT1 and paternal alcoholism may operate differently across genders and races. |
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Authors:
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Jamie Vaske; Kevin M Beaver; John Paul Wright; Danielle Boisvert; Rebecca Schnupp |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S. Date: 2009-05-13 |
Journal Detail:
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Title: Drug and alcohol dependence Volume: 104 ISSN: 1879-0046 ISO Abbreviation: Drug Alcohol Depend Publication Date: 2009 Sep |
Date Detail:
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Created Date: 2009-07-20 Completed Date: 2009-09-29 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7513587 Medline TA: Drug Alcohol Depend Country: Ireland |
Other Details:
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Languages: eng Pagination: 17-22 Citation Subset: IM |
Affiliation:
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Division of Criminal Justice, University of Cincinnati, Cincinnati, OH 45221-0389, USA. vaskeje@email.uc.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent African Americans Alcoholism / epidemiology*, genetics* Dopamine Plasma Membrane Transport Proteins / genetics* Ethnic Groups European Continental Ancestry Group Fathers Female Gene Frequency Genotype Humans Male Minisatellite Repeats Predictive Value of Tests Sex Characteristics Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Dopamine Plasma Membrane Transport Proteins; 0/SLC6A3 protein, human |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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