| The integrity of the esophageal mucosa. Balance between offensive and defensive mechanisms. | |
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MedLine Citation:
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PMID: 21126700 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Heartburn is the most common and characteristic symptom of gastroesophageal reflux disease. It ultimately results from contact of refluxed gastric acid with nociceptors within the esophageal mucosa and transmission of this peripheral signal to the central nervous system for cognition. Healthy esophageal epithelium provides an effective barrier between refluxed gastric acid and esophageal nociceptors; but this barrier is vulnerable to attack and damage, particularly by acidic gastric contents. How gastric acid is countered by defensive elements within the esophageal mucosa is a major focus of this discussion. When the defense is successful, the subject is asymptomatic and when unsuccessful, the subject experiences heartburn. Those with heartburn commonly fall into one of three endoscopic types: nonerosive reflux disease, erosive esophagitis and Barrett's esophagus. Although what determines endoscopic type remains unknown; it is proposed herein that inflammation plays a key, modulating role. |
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Authors:
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Roy C Orlando |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Best practice & research. Clinical gastroenterology Volume: 24 ISSN: 1532-1916 ISO Abbreviation: Best Pract Res Clin Gastroenterol Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-12-03 Completed Date: 2011-03-21 Revised Date: 2011-12-21 |
Medline Journal Info:
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Nlm Unique ID: 101120605 Medline TA: Best Pract Res Clin Gastroenterol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 873-82 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier Ltd. All rights reserved. |
Affiliation:
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University of North Carolina at Chapel Hill, 27599, USA. rorlando@med.unc.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Barrett Esophagus / etiology, metabolism*, pathology, physiopathology Biological Transport Endoscopy, Gastrointestinal Esophagitis / etiology, metabolism*, pathology, physiopathology Esophagus / blood supply, metabolism*, pathology, physiopathology Gastric Acid / metabolism* Gastroesophageal Reflux / complications, metabolism*, pathology, physiopathology Heartburn / etiology, metabolism Humans Mucous Membrane / metabolism Permeability Regional Blood Flow |
| Grant Support | |
ID/Acronym/Agency:
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R37 DK036013-22/DK/NIDDK NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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