| Tup/Islet1 integrates time and position to specify muscle identity in Drosophila. | |
| | |
MedLine Citation:
|
PMID: 22949613 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
The LIM-homeodomain transcription factor Tailup/Islet1 (Tup) is a key component of cardiogenesis in Drosophila and vertebrates. We report here an additional major role for Drosophila Tup in specifying dorsal muscles. Tup is expressed in the four dorsal muscle progenitors (PCs) and tup-null embryos display a severely disorganized dorsal musculature, including a transformation of the dorsal DA2 into dorsolateral DA3 muscle. This transformation is reciprocal to the DA3 to DA2 transformation observed in collier (col) mutants. The DA2 PC, which gives rise to the DA2 muscle and to an adult muscle precursor, is selected from a cluster of myoblasts transiently expressing both Tinman (Tin) and Col. The activation of tup by Tin in the DA2 PC is required to repress col transcription and establish DA2 identity. The transient, partial overlap between Tin and Col expression provides a window of opportunity to distinguish between DA2 and DA3 muscle identities. The function of Tup in the DA2 PC illustrates how single cell precision can be reached in cell specification when temporal dynamics are combined with positional information. The contributions of Tin, Tup and Col to patterning Drosophila dorsal muscles bring novel parallels with chordate pharyngeal muscle development. |
| | |
Authors:
|
Hadi Boukhatmi; Jean Louis Frendo; Jonathan Enriquez; Michèle Crozatier; Laurence Dubois; Alain Vincent |
Related Documents
:
|
7450393 - The regional difference in the responses of the guinea pig gastric muscles to gastrin. 9485523 - Influence of acidification on biphasic contractile response of guinea pig vas deferens ... 23400913 - Validity and reliability of nerve and muscle ultrasound. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Development (Cambridge, England) Volume: 139 ISSN: 1477-9129 ISO Abbreviation: Development Publication Date: 2012 Oct |
Date Detail:
|
Created Date: 2012-09-05 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8701744 Medline TA: Development Country: England |
Other Details:
|
Languages: eng Pagination: 3572-82 Citation Subset: IM |
Affiliation:
|
Université de Toulouse 3, Centre de Biologie du Développement, UMR 5547 CNRS and FRBT, 118 route de Narbonne, F-31062 Toulouse cedex 09, France. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Tooth shape formation and tooth renewal: evolving with the same signals.
Next Document: SPACA1-deficient male mice are infertile with abnormally shaped sperm heads reminiscent of globozoos...