Document Detail

An integrated organismic response to lower gut stimulation.
MedLine Citation:
PMID:  6605574     Owner:  NLM     Status:  MEDLINE    
Lean Sprague-Dawley rats underwent surgery in which 10 or 20 cm of the lower ileum was transposed to the middle of the duodenum. After the surgery, food passed through the stomach and upper duodenum before moving into the transposed ileal segment. Unabsorbed food moved on into the lower duodenum and continued down the rest of the digestive tract. Control rats had either 20 cm of ileum removed from normal continuity or had 20 cm of jejunum transposed to mid-duodenum. Ileal transposition led to a reduction in food intake and a loss of body weight that depended on the length of the transposed segment. These changes were most striking in the second 10-day post-surgical period. At sacrifice, the stomach and small intestines were significantly enlarged even though the transposed rats had lost about 10% of their body weight. The pancreas increased significantly in relative weight. These behavioural and physiological changes are interpreted as an integrated response that prevents undigested food from reaching the terminal ileum in an animal with normal intestinal continuity. A second experiment with Lewis parabiotic rats confirmed that stimulation of the lower small intestines, cecum and colon is involved in the normal control of food intake. Rats that had an unstimulated lower gut increased food intake while those that had their lower gut doubly stimulated with undigested chyme, reduced their intake.
H S Koopmans
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Scandinavian journal of gastroenterology. Supplement     Volume:  82     ISSN:  0085-5928     ISO Abbreviation:  Scand. J. Gastroenterol. Suppl.     Publication Date:  1983  
Date Detail:
Created Date:  1983-12-17     Completed Date:  1983-12-17     Revised Date:  2008-02-13    
Medline Journal Info:
Nlm Unique ID:  0437034     Medline TA:  Scand J Gastroenterol Suppl     Country:  NORWAY    
Other Details:
Languages:  eng     Pagination:  143-53     Citation Subset:  IM    
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MeSH Terms
Body Weight
Cecum / physiology*
Colon / physiology*
Ileum / physiology*,  surgery
Intestines / anatomy & histology
Organ Size
Pancreas / anatomy & histology
Rats, Inbred Lew
Rats, Inbred Strains
Stomach / anatomy & histology
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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