| An integrated model for the prediction of preeclampsia using maternal factors and uterine artery Doppler velocimetry in unselected low-risk women. | |
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MedLine Citation:
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PMID: 16098866 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: The purpose of this study was to develop a predictive model for preeclampsia. STUDY DESIGN: This was a prospective screening study for preeclampsia using uterine artery Doppler ultrasound in unselected low-risk singleton pregnancies at community hospitals in the UK (n = 32,157). Logistic regression models were developed and their predictive ability assessed using the area under the receiver operator curve (AROC). RESULTS: Six hundred twelve (2.0%) women developed preeclampsia, and 144 (0.5%) required early delivery (<34 weeks). A model using both maternal and ultrasound factors had an AROC of 0.798, which was higher than ultrasound alone (0.729, P < .0001) or maternal factors alone (0.712, P < .0001). In early onset disease, the ROC of ultrasound alone (0.922) was not significantly improved by adding maternal predictors (0.945, P = .27). In contrast, late onset disease was better predicted by the combined model (AROC 0.798) than ultrasound alone (AROC 0.729, P < .0001) or maternal factors alone (AROC 0.712, P < .0001). CONCLUSION: The combination of uterine artery Doppler ultrasound and maternal factors provided the best estimate of risk. |
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Authors:
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Christina K H Yu; Gordon C S Smith; Aris T Papageorghiou; Ana Maria Cacho; Kypros H Nicolaides; |
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Publication Detail:
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Type: Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: American journal of obstetrics and gynecology Volume: 193 ISSN: 0002-9378 ISO Abbreviation: Am. J. Obstet. Gynecol. Publication Date: 2005 Aug |
Date Detail:
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Created Date: 2005-08-15 Completed Date: 2005-09-15 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370476 Medline TA: Am J Obstet Gynecol Country: United States |
Other Details:
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Languages: eng Pagination: 429-36 Citation Subset: AIM; IM |
Affiliation:
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Harris Birthright Research Centre for Fetal Medicine, King's College Hospital Medical School, Denmark Hill, London, UK. chrissieyu@aol.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Female Humans Laser-Doppler Flowmetry* Logistic Models* Pre-Eclampsia / epidemiology*, physiopathology, ultrasonography Pregnancy Prospective Studies ROC Curve Risk Assessment Sensitivity and Specificity Ultrasonography, Doppler Uterus / blood supply* Vagina / blood supply |
| Comments/Corrections | |
Comment In:
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Am J Obstet Gynecol. 2006 Jul;195(1):330
[PMID:
16813764
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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