Document Detail

An integrated model of the human ventilatory control system: the response to hypoxia.
MedLine Citation:
PMID:  11442579     Owner:  NLM     Status:  MEDLINE    
The mathematical model of the respiratory control system described in a previous companion paper is used to analyse the ventilatory response to hypoxic stimuli. Simulation of long-lasting isocapnic hypoxia at normal alveolar PCO2 (40 mmHg=5.33 kPa) shows the occurrence of a biphasic response, characterized by an initial peak and a subsequent hypoxic ventilatory decline (HVD). The latter is about as great as 2/3 of the initial peak and can be mainly ascribed to prolonged neural hypoxia. If isocapnic hypoxia is performed during hypercapnia (PACO2=48 mmHg =6.4 kPa), the ventilatory response is stronger and HVD is minimal (about 1/10-1/5 of the initial peak). During poikilocapnic hypoxia, ventilation exhibits smaller changes compared with the isocapnic case, with a rapid return toward baseline within a few minutes. Moreover, a significant undershoot occurs at the termination of the hypoxic period. This undershoot may lead to apnea and to a transient destabilization of the control system if the peripheral chemoreflex gain and time delay are twofold greater than basal.
M Ursino; E Magosso; G Avanzolini
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical physiology (Oxford, England)     Volume:  21     ISSN:  0144-5979     ISO Abbreviation:  Clin Physiol     Publication Date:  2001 Jul 
Date Detail:
Created Date:  2001-07-09     Completed Date:  2001-08-30     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8309768     Medline TA:  Clin Physiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  465-77     Citation Subset:  IM    
Department of Electronics, Computer Science and Systems, University of Bologna, Bologna, Italy.
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MeSH Terms
Anoxia / physiopathology*
Apnea / physiopathology
Carbon Dioxide / blood
Chemoreceptor Cells / physiology*
Hypercapnia / physiopathology
Models, Theoretical*
Respiratory Physiological Phenomena*
Reg. No./Substance:
124-38-9/Carbon Dioxide

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