| An integrated approach to diabetic retinopathy research. | |
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MedLine Citation:
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PMID: 21320973 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This review discusses the pathophysiology of diabetic retinopathy related to direct effects of loss of insulin receptor action and metabolic dysregulation on the retina. The resulting sensory neuropathy can be diagnosed by structural and functional tests in patients with mild nonproliferative diabetic retinopathy. Research teams can collaborate to integrate ocular and systemic factors that impair vision and to design strategies to maintain retinal function in persons with diabetes mellitus. Evolving concepts may lead to inclusion of tests of retinal function in the detection of diabetic retinopathy and neuroprotective strategies to preserve vision for persons with diabetes. |
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Authors:
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Thomas W Gardner; Steven F Abcouwer; Alistair J Barber; Gregory R Jackson |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Archives of ophthalmology Volume: 129 ISSN: 1538-3601 ISO Abbreviation: Arch. Ophthalmol. Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-02-15 Completed Date: 2011-03-24 Revised Date: 2012-02-02 |
Medline Journal Info:
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Nlm Unique ID: 7706534 Medline TA: Arch Ophthalmol Country: United States |
Other Details:
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Languages: eng Pagination: 230-5 Citation Subset: AIM; IM |
Affiliation:
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Kellogg Eye Center, 1000 Wall St., Ann Arbor, MI 48105, USA. tomwgard@umich.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Biomedical Research* Diabetes Mellitus / physiopathology Diabetic Retinopathy / complications*, physiopathology Humans Receptor, Insulin / metabolism Retina / metabolism, physiopathology |
| Grant Support | |
ID/Acronym/Agency:
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EY020582/EY/NEI NIH HHS; R01 EY020582-01/EY/NEI NIH HHS |
| Chemical | |
Reg. No./Substance:
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EC 2.7.10.1/Receptor, Insulin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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