| An integrated CMOS high voltage supply for lab-on-a-chip systems. | |
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MedLine Citation:
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PMID: 18818808 Owner: NLM Status: PubMed-not-MEDLINE |
Abstract/OtherAbstract:
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Electrophoresis is a mainstay of lab-on-a-chip (LOC) implementations of molecular biology procedures and is the basis of many medical diagnostics. High voltage (HV) power supplies are necessary in electrophoresis instruments and are a significant part of the overall system cost. This cost of instrumentation is a significant impediment to making LOC technologies more widely available. We believe one approach to overcoming this problem is to use microelectronic technology (complementary metal-oxide semiconductor, CMOS) to generate and control the HV. We present a CMOS-based chip (3 mm x 2.9 mm) that generates high voltages (hundreds of volts), switches HV outputs, and is powered by a 5 V input supply (total power of 28 mW) while being controlled using a standard computer serial interface. Microchip electrophoresis with laser induced fluorescence (LIF) detection is implemented using this HV CMOS chip. With the other advancements made in the LOC community (e.g. micro-fluidic and optical devices), these CMOS chips may ultimately enable 'true' LOC solutions where essentially all the microfluidics, photonics and electronics are on a single chip. |
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Authors:
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M Behnam; G V Kaigala; M Khorasani; P Marshall; C J Backhouse; D G Elliott |
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Publication Detail:
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Type: Journal Article Date: 2008-07-21 |
Journal Detail:
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Title: Lab on a chip Volume: 8 ISSN: 1473-0197 ISO Abbreviation: Lab Chip Publication Date: 2008 Sep |
Date Detail:
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Created Date: 2008-09-26 Completed Date: 2008-10-10 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101128948 Medline TA: Lab Chip Country: England |
Other Details:
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Languages: eng Pagination: 1524-9 Citation Subset: - |
Affiliation:
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Department of Electrical and Computer Engineering, University of Edmonton, AB, T6G 2V4, Canada. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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