Document Detail

The insulin response and glucose tolerance in acute pancreatitis with reference to patients body weight.
MedLine Citation:
PMID:  6762299     Owner:  NLM     Status:  MEDLINE    
In 32 nonobese and 8 obese patients with acute pancreatitis [AP] and 12 control subjects the insulin response to oral and intravenous glucose load was studied. It has been shown, that secretion of insulin after oral glucose was significantly impaired and delayed in nonobese patients in comparison to control. Contrary, the hyperinsulinic response was evident in obese patients. Any significant difference of insulin secretion after intravenous glucose in nonobese patients and controls were not observed. The hyperinsulinic response in 8 obese patients with AP after i.v. glucose was even more evident than after oral glucose load. In both groups of patients with AP, the coefficient of glucose utilisation was diminished. The results indicate a significant impairment of glucose-insulin interrelations during early stages of acute pancreatitis and suggest the influence of obesity on insulin response in this disease.
J Dlugosz; S Olszewski; I Kinalska; A Gabryelewicz
Related Documents :
1980259 - Normal inhibition by somatostatin of glucose-stimulated b cell secretion in the obese s...
19073769 - Variants near mc4r are associated with obesity and influence obesity-related quantitati...
1554469 - Inner ear damage secondary to diabetes mellitus. ii. changes in aging shr/n-cp rats.
15811139 - Abdominal obesity predicts declining insulin sensitivity in non-obese normoglycaemics: ...
6751729 - Fenfluramine therapy in non-insulin-dependent diabetic patients: effects on body weight...
7562549 - Prophylaxis of genetically determined diabetes by diazoxide: a study in a rat model of ...
16394109 - Leukocyte recruitment and vascular injury in diabetic nephropathy.
19273569 - Altered insulin requirement in patients with type 1 diabetes and primary adrenal insuff...
23125509 - Strengthening of antioxidant defense by azadirachta indica in alloxan-diabetic rat tiss...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Deutsche Zeitschrift für Verdauungs- und Stoffwechselkrankheiten     Volume:  42     ISSN:  0012-1053     ISO Abbreviation:  Dtsch Z Verdau Stoffwechselkr     Publication Date:  1982  
Date Detail:
Created Date:  1983-05-27     Completed Date:  1983-05-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372760     Medline TA:  Dtsch Z Verdau Stoffwechselkr     Country:  GERMANY, EAST    
Other Details:
Languages:  eng     Pagination:  295-9     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Acute Disease
Body Weight*
Glucose Tolerance Test*
Insulin / secretion*
Middle Aged
Obesity / metabolism
Pancreatitis / metabolism*
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  The history of hepatology from Galen to Frerichs
Next Document:  Immunoperoxidase demonstration of Chlamydia inclusions in routine Pap-smears.