Document Detail

An institutional study on thymomas and thymic carcinomas: experience in 77 patients.
MedLine Citation:
PMID:  18365972     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Thymomas and thymic carcinomas are rare tumors of the anterior mediastinum. A WHO classification was introduced in 1999, which has been updated in 2004. Meanwhile, several retrospective studies have been carried out which have shown the prognostic significance of this classification together with Masaoka's staging system and the extent of surgery. PATIENTS AND METHODS: Between 1983 and 2000, 77 patients (37 male, 40 female) underwent resection of thymomas and thymic carcinomas in our institution. Complete resection was achieved in 57 patients. The median follow-up was 72.6 months. RESULTS: The overall 5-year survival rate was 71.4 %. The factors "histology" and "extent of resection" had the most important impact on survival. However, even among the patients with complete resection, 12 of them suffered a relapse. Among this patient group, the most important factors for disease-free survival were "tumor stage" and "histology". Patients with an incomplete resection had a 5-year survival rate of only 29 % in spite of adjuvant radiation and/or chemotherapy. Due to the high rate of relapse, the poor survival rate found in incompletely resected patients as well as the failure of classical chemotherapy regimens, especially in type B2 and type B3 thymomas and thymic carcinomas, the search for new chemotherapeutic schemes is mandatory. CONCLUSION: Our study shows that there are still encouraging therapeutic options for thymomas and thymic carinomas. Type B2, type B3 thymomas and thymic carcinomas have worse outcomes in spite of adjuvant chemo- and radiotherapies. Especially in patients with incomplete surgical resection the outcome remains poor.
R J Rieker; T Muley; C Klein; P A Schnabel; E Herpel; M Meister; P Schirmacher; H Dienemann; J Pfannschmidt
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  The Thoracic and cardiovascular surgeon     Volume:  56     ISSN:  0171-6425     ISO Abbreviation:  Thorac Cardiovasc Surg     Publication Date:  2008 Apr 
Date Detail:
Created Date:  2008-03-27     Completed Date:  2008-08-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7903387     Medline TA:  Thorac Cardiovasc Surg     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  143-7     Citation Subset:  IM    
Department of Pathology, University of Heidelberg, Amalienstrasse 5, Heidelberg, Germany.
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MeSH Terms
Carcinoma / classification*,  pathology,  surgery
Diagnosis, Differential
Follow-Up Studies
Hospitals, University / statistics & numerical data*
Middle Aged
Neoplasm Staging
Retrospective Studies
Severity of Illness Index
Thymectomy / methods*
Thymoma / classification*,  pathology,  surgery
Thymus Neoplasms / classification*,  pathology,  surgery

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