| An insight on the neuropharmacological activity of Telescopium telescopium--a mollusc from the Sunderban mangrove. | |
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MedLine Citation:
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PMID: 19049673 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The present study was carried out to evaluate the biological properties of the tissue extract of a marine snail Telescopium telescopium, collected from the coastal regions of West Bengal India. On extensive pharmacological screening, it was found that the biological extract of T. telescopium (TTE) produced significant central nervous system (CNS)-depressant activity as observed from the reduced spontaneous motility, potentiation of pentobarbitone induced sleeping time, hypothermia and respiratory depression with transient apnoea. The extract significantly decreased both residual curiosity and also muscle coordination. The fraction, obtained following saturation with 60-80% ammonium sulphate (80S), was also found to demonstrate predominant CNS-depressant activity. It was observed that both TTE and the 80S fraction significantly altered the brain noradrenaline and homovanillic acid levels without affecting the brain gamma amino butyric acid (GABA) concentration. Based on the present observations, it can be suggested that the CNS-depressant effects produced by TTE and 80S could be attributable to modified catecholamine metabolism in the brain. |
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Authors:
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S K Samanta; K T Manisenthil Kumar; Amrita Roy; S Karmakar; Shawon Lahiri; G Palit; J R Vedasiromoni; T Sen |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Fundamental & clinical pharmacology Volume: 22 ISSN: 1472-8206 ISO Abbreviation: Fundam Clin Pharmacol Publication Date: 2008 Dec |
Date Detail:
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Created Date: 2008-12-03 Completed Date: 2009-02-17 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8710411 Medline TA: Fundam Clin Pharmacol Country: England |
Other Details:
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Languages: eng Pagination: 683-91 Citation Subset: IM |
Affiliation:
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Division of Pharmacology, Department of Pharmaceutical Technology, Jadavpur University, Kolkata 700032, India. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Behavior, Animal / drug effects Body Temperature / drug effects Brain / drug effects*, metabolism Central Nervous System Depressants / pharmacology*, toxicity Disease Models, Animal Dose-Response Relationship, Drug Electrophoresis, Polyacrylamide Gel Exploratory Behavior / drug effects Homovanillic Acid / metabolism India Lethal Dose 50 Male Mice Motor Activity / drug effects Muscle Relaxation / drug effects Norepinephrine / metabolism Rats Respiratory Mechanics / drug effects Seizures / prevention & control Sleep / drug effects Snails* Tissue Extracts / pharmacology*, toxicity gamma-Aminobutyric Acid / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Central Nervous System Depressants; 0/Tissue Extracts; 306-08-1/Homovanillic Acid; 51-41-2/Norepinephrine; 56-12-2/gamma-Aminobutyric Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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