Document Detail


An insight into normal and pathological pregnancies using large-scale microarrays: lessons from microarrays.
MedLine Citation:
PMID:  21329986     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
In the introduction, we briefly recall old but classic evidence that there is no tolerance to paternal alloantigens in a first pregnancy. Therefore, we performed small- and large-scale microarrays in CBA×DBA/2 and CBA×BALB/c combinations, recently described as a murine model for preeclampsia. Our results are in line with other data suggesting a very early deregulation of local immune vascular events rather than a break of immune tolerance. Other data presented at the Tioman 2010 Preeclampsia Workshop supporting this hypothesis are briefly summarised, as well as indications and caveats from a recent human microarray on implantation failure and recurrent pregnancy loss.
Authors:
Gérard Chaouat; Nathalie Rodde; Marie Petitbarat; Roberta Bulla; Mona Rahmati; Sylvie Dubanchet; Sandrine Zourbas; Isabelle Bataillon; Nathalie Coqué; Benoit Hennuy; Jacques Martal; Carine Munaut; Julie Aubert; Valérie Sérazin; Thiel Steffen; Jens Christian Jensenius; Jean Michel Foidart; Olivier Sandra; Francesco Tedesco; Nathalie Lédée
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-2-15
Journal Detail:
Title:  Journal of reproductive immunology     Volume:  -     ISSN:  1872-7603     ISO Abbreviation:  -     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-2-18     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8001906     Medline TA:  J Reprod Immunol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.
Affiliation:
INSERM U782, UMR 0782, Hôpital Béclère, Clamart, and University Paris XI, Orsay, France.
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