| An inside job: subversion of the host secretory pathway by intestinal pathogens. | |
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MedLine Citation:
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PMID: 20717028 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE OF REVIEW: The cellular secretory pathway, composed of the endoplasmic reticulum, Golgi apparatus, and cellular vesicles, mediates the intracellular trafficking of proteins and lipids. Gastrointestinal pathogens frequently affect the functions of enterocytes, the differentiated cells involved in secretion and absorption of extracellular molecules. Microbial pathogenesis can be enhanced by altering the trafficking of key molecules such as brush border enzymes, soluble immune mediators such as cytokines and chemokines, and MHC Class I molecules, all of which rely on the secretory pathway for their appropriate cellular localization. This review focuses on our current understanding of the distinct mechanisms employed by enteric pathogens to antagonize the secretory pathway. RECENT FINDINGS: Many pathogens encode individual or multiple proteins to antagonize the secretory pathway, including disrupting the trafficking of vesicles between the endoplasmic reticulum, Golgi, and plasma membrane. This antagonism allows for increased pathogenesis and can assist, directly or indirectly, in microbial replication. Virtually all arms of the secretory pathway are targeted by intestinal pathogens, supporting the pathogenic significance of shutting this pathway down. SUMMARY: This review summarizes the mechanisms utilized by gut pathogens to disrupt the cellular secretory pathway and addresses potential therapeutic targets to combat these highly prevalent and burdensome microbes. |
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Authors:
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Tyler M Sharp; Mary K Estes |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.; Review |
Journal Detail:
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Title: Current opinion in infectious diseases Volume: 23 ISSN: 1473-6527 ISO Abbreviation: Curr. Opin. Infect. Dis. Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-08-25 Completed Date: 2010-11-30 Revised Date: 2012-01-31 |
Medline Journal Info:
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Nlm Unique ID: 8809878 Medline TA: Curr Opin Infect Dis Country: United States |
Other Details:
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Languages: eng Pagination: 464-9 Citation Subset: IM |
Affiliation:
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Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Enterocytes
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metabolism* Escherichia coli / pathogenicity* Host-Pathogen Interactions* Humans Norovirus / pathogenicity* Picornaviridae / pathogenicity* Protein Transport Rotavirus / pathogenicity* Secretory Pathway* Virulence Factors / metabolism |
| Grant Support | |
ID/Acronym/Agency:
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P01 AI05778/AI/NIAID NIH HHS; P30 DK 56338/DK/NIDDK NIH HHS; R01 AI080656/AI/NIAID NIH HHS; T32 AI04741/AI/NIAID NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Virulence Factors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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