Document Detail


The inner nuclear envelope as a transcription factor resting place.
MedLine Citation:
PMID:  17906672     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Just as people head to the beaches for a well-deserved rest, accumulating evidence suggests that transcription factors take similar 'vacations' at the nuclear envelope. Recent studies indicate that the periphery of the nucleus provides a platform for sequestering transcription factors away from chromatin. Several transcriptional regulators, operating in different signal-transduction pathways, have been found to interact physically with components of the inner nuclear membrane. In general, this association seems to restrict access to their target genes and limit their transactivation or transrepression abilities. The mechanisms of inner nuclear membrane association are diverse, and include regulated associations with the nuclear lamina and integral membrane proteins. Together, these findings indicate that the inside of the nuclear envelope functions as a resting place for transcription factors and suggest a more direct role for the nuclear envelope in gene regulation than previously anticipated.
Authors:
Stijn Heessen; Maarten Fornerod
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  EMBO reports     Volume:  8     ISSN:  1469-221X     ISO Abbreviation:  EMBO Rep.     Publication Date:  2007 Oct 
Date Detail:
Created Date:  2007-10-01     Completed Date:  2008-02-26     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  100963049     Medline TA:  EMBO Rep     Country:  England    
Other Details:
Languages:  eng     Pagination:  914-9     Citation Subset:  IM    
Affiliation:
Department of Tumour Biology, Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands.
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MeSH Terms
Descriptor/Qualifier:
Animals
Humans
Lamins / metabolism
Models, Biological
Nuclear Envelope / metabolism*
Nuclear Lamina / metabolism
Nuclear Proteins / metabolism
Signal Transduction
Transcription Factors / metabolism*
Chemical
Reg. No./Substance:
0/Lamins; 0/Nuclear Proteins; 0/Transcription Factors
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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