Document Detail

An injury model myopathy mimicking dystrophy: implications regarding the function of dystrophin.
MedLine Citation:
PMID:  1943889     Owner:  NLM     Status:  MEDLINE    
The pathogenesis of dystrophin deficient myopathies remains unknown. Rat and human muscles subjected to severe injury following repeated eccentric muscle actions demonstrate histopathological alterations which mimic a dystrophic process. Immunofluorescent histochemical examination of these injured muscles demonstrates a separation of proteoglycans of the basal lamina from the muscle plasma membrane, the identical histopathological alteration observed in Duchenne muscular dystrophy. These findings are consistent with the hypothesis that dystrophin is essential for maintenance of the structural integrity of the sarcolemma.
W T Stauber; V K Fritz; P M Clarkson; J E Riggs
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Medical hypotheses     Volume:  35     ISSN:  0306-9877     ISO Abbreviation:  Med. Hypotheses     Publication Date:  1991 Aug 
Date Detail:
Created Date:  1991-12-13     Completed Date:  1991-12-13     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7505668     Medline TA:  Med Hypotheses     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  358-62     Citation Subset:  IM    
Department of Physiology, West Virginia University, Morgantown 26506.
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MeSH Terms
Disease Models, Animal
Dystrophin / physiology*
Electric Stimulation
Muscle Contraction
Muscles / injuries*,  pathology,  physiopathology
Muscular Dystrophies / etiology*
Muscular Dystrophy, Animal / etiology,  physiopathology*
Rats, Inbred Strains
Reg. No./Substance:

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