| The initiation of erythropoiesis following renal transplantation. | |
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MedLine Citation:
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PMID: 2517329 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Erythropoiesis has been examined in relation to kidney function in 38 patients during the 3-month period following successful renal transplantation, using serial determinations of erythropoietin, haemoglobin, and creatinine. Two peaks of serum erythropoietin were observed: an early peak that occurred within 2 days of transplantation and was observed in ten patients, and a late one between 8 and 30 days, observed in 28 patients. The early peak did not produce an increase in haemoglobin and occurred only in the presence of delayed onset of graft excretory function when serum creatinine was greater than 1000 mumols/l. The ineffectiveness of the early peak may be due to the uraemic environment, which is probably a sequel of the tubular damage associated with postoperative acute tubular necrosis. The late peak followed a decrease in serum creatinine to less than 200 mumols/l and was associated with an increase in haemoglobin of 3-4 g/dl during the next 2-6 weeks. |
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Authors:
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J H Brown; T R Lappin; G E Elder; T N Taylor; J M Bridges; M G McGeown |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association Volume: 4 ISSN: 0931-0509 ISO Abbreviation: Nephrol. Dial. Transplant. Publication Date: 1989 |
Date Detail:
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Created Date: 1990-05-17 Completed Date: 1990-05-17 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8706402 Medline TA: Nephrol Dial Transplant Country: GERMANY |
Other Details:
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Languages: eng Pagination: 1076-9 Citation Subset: IM |
Affiliation:
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Renal Unit, Belfast City Hospital. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Anemia / therapy Child Creatinine / blood Erythropoiesis / drug effects* Erythropoietin / metabolism Female Hemoglobins / metabolism Humans Immunosuppressive Agents / adverse effects, therapeutic use Kidney Failure, Chronic / therapy Kidney Transplantation / physiology* Male Middle Aged Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Hemoglobins; 0/Immunosuppressive Agents; 11096-26-7/Erythropoietin; 60-27-5/Creatinine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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