| The initial clinical experience with an implantable cardioverter defibrillator/antitachycardia pacemaker. | |
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MedLine Citation:
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PMID: 1715549 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Guardian antitachycardia pacing (ATP) 4210 is a third generation, multi-programmable cardioverter defibrillator undergoing Phase I clinical trials. The tiered response includes ATP, low energy cardioversion or defibrillation, and bradycardia support. Extensive telemetry is available, including an episode log and details of all episode events. Five patients underwent the implantation of Guardian ATP 4210 as part of a Phase I trial at the University of Louisville. Two of the five patients had multiple VT episodes that were reverted successfully using ATP pacing (slow VT) and defibrillation (fast VT) and VF episodes, which resulted in defibrillation therapy over a follow-up period of 6 to 8 months. Four of the five patients required bradycardia support for bradyarrhythmias unassociated with ATP therapy or defibrillation and one patient required bradycardia support postdefibrillation therapy. The device design is microprocessor based and requires continuous interrogation of the microprocessor memory and checks of the validity of programmed parameters to continue its operation. When the safety check fails, the device is designed to shut down its antitachycardia and defibrillator functions. This design feature has a potential for leaving the patient unprotected if the device shuts down. Modification of this feature is required to ensure the device's long-term safety. |
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Authors:
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I Singer; E Austin; W Nash; J Gilbo; J Kupersmith |
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Publication Detail:
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Type: Clinical Trial; Journal Article |
Journal Detail:
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Title: Pacing and clinical electrophysiology : PACE Volume: 14 ISSN: 0147-8389 ISO Abbreviation: Pacing Clin Electrophysiol Publication Date: 1991 Jul |
Date Detail:
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Created Date: 1991-10-02 Completed Date: 1991-10-02 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7803944 Medline TA: Pacing Clin Electrophysiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1119-28 Citation Subset: IM |
Affiliation:
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Cardiovascular Division, University of Louisville, Kentucky 40292. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Electric Countershock / instrumentation* Electrocardiography Female Follow-Up Studies Heart Ventricles Humans Male Middle Aged Pacemaker, Artificial* Prostheses and Implants* Tachycardia / physiopathology, therapy* Ventricular Fibrillation / therapy |
| Comments/Corrections | |
Comment In:
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Pacing Clin Electrophysiol. 1991 Oct;14(10):1554-5
[PMID:
1721138
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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