| Tel/PDGFRbeta inhibits self-renewal and directs myelomonocytic differentiation of ES cells. | |
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MedLine Citation:
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PMID: 18355917 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The leukemic oncogene Tel/PDGFRbeta, was inducibly expressed in embryonic stem (ES) cells and the phenotypic and molecular changes occurring during hematopoietic differentiation investigated. Expression of Tel/PDGFRbeta resulted in an inability of ES cells to self-renew and caused a significant increase in myelopoiesis with a corresponding decrease in erythropoiesis. Analysis of gene expression patterns indicated a dramatic alteration in the levels of genes associated with self-renewal and differentiation, especially myelomonocytic genes in Tel/PDGFRbeta-expressing cells. This study indicates Tel/PDGFRbeta drives myelopoiesis by altering expression of genes involved in hematopoiesis and demonstrates the potential of this stem cell system to study oncogene-induced pathogenesis. |
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Authors:
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E Dobbin; P M Corrigan; C P Walsh; M J Welham; R W Freeburn; H Wheadon |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2008-03-19 |
Journal Detail:
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Title: Leukemia research Volume: 32 ISSN: 0145-2126 ISO Abbreviation: Leuk. Res. Publication Date: 2008 Oct |
Date Detail:
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Created Date: 2008-06-13 Completed Date: 2008-08-28 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7706787 Medline TA: Leuk Res Country: England |
Other Details:
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Languages: eng Pagination: 1554-64 Citation Subset: IM |
Affiliation:
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Biomedical Sciences Research Institute, University of Ulster, Cromore Road, Coleraine, Northern Ireland, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Differentiation Cell Proliferation Cell Survival Cells, Cultured Embryonic Stem Cells / cytology, metabolism* Gene Expression Regulation Hematopoiesis / genetics Leukemia Inhibitory Factor / pharmacology Mice Myeloid Cells / cytology Myelopoiesis* Oncogene Proteins, Fusion / metabolism* |
| Grant Support | |
ID/Acronym/Agency:
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//Medical Research Council |
| Chemical | |
Reg. No./Substance:
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0/Leukemia Inhibitory Factor; 0/Oncogene Proteins, Fusion; 0/TEL-PDGFRbeta fusion protein, human |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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