| An inhibitory role of beta-endorphin in central cardiovascular regulation. | |
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MedLine Citation:
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PMID: 6285113 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The cardiovascular effects of beta-endorphin after administration directly into the nucleus tractus solitarii (NTS) of urethane anaesthetised rats were investigated. Unilateral injection resulted in a dose related fall in mean arterial pressure and heart rate. No change in respiratory frequency was prevented and the bradycardia reduced by pretreatment with locally applied naloxone (10 ng). This dose of the opiate antagonist had no effect on mean arterial pressure or heart rate when administered alone. Antiserum to beta-endorphin (1:50 dilution) caused a rise in pressure and a tendency towards tachycardia on injection into the NTS, while it completely blocked the depressor response and bradycardia induced by beta-endorphin. These results are consistent with the view that a beta-endorphin-like peptide has a depressor role in the central nervous system. The hypotension may result from an effect within the central connections of the baroreceptor reflex arc, probably at the level of the NTS. |
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Authors:
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M A Petty; W de Jong; D de Wied |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Life sciences Volume: 30 ISSN: 0024-3205 ISO Abbreviation: Life Sci. Publication Date: 1982 May |
Date Detail:
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Created Date: 1982-09-24 Completed Date: 1982-09-24 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0375521 Medline TA: Life Sci Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 1835-40 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anti-Arrhythmia Agents* Blood Pressure / drug effects Cardiovascular System / drug effects* Endorphins / antagonists & inhibitors, pharmacology* Heart Rate / drug effects Male Medulla Oblongata / drug effects Naloxone / pharmacology Rats Rats, Inbred Strains beta-Endorphin |
| Chemical | |
Reg. No./Substance:
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0/Anti-Arrhythmia Agents; 0/Endorphins; 465-65-6/Naloxone; 60617-12-1/beta-Endorphin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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