Document Detail

An inhibitory role of beta-endorphin in central cardiovascular regulation.
MedLine Citation:
PMID:  6285113     Owner:  NLM     Status:  MEDLINE    
The cardiovascular effects of beta-endorphin after administration directly into the nucleus tractus solitarii (NTS) of urethane anaesthetised rats were investigated. Unilateral injection resulted in a dose related fall in mean arterial pressure and heart rate. No change in respiratory frequency was prevented and the bradycardia reduced by pretreatment with locally applied naloxone (10 ng). This dose of the opiate antagonist had no effect on mean arterial pressure or heart rate when administered alone. Antiserum to beta-endorphin (1:50 dilution) caused a rise in pressure and a tendency towards tachycardia on injection into the NTS, while it completely blocked the depressor response and bradycardia induced by beta-endorphin. These results are consistent with the view that a beta-endorphin-like peptide has a depressor role in the central nervous system. The hypotension may result from an effect within the central connections of the baroreceptor reflex arc, probably at the level of the NTS.
M A Petty; W de Jong; D de Wied
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Life sciences     Volume:  30     ISSN:  0024-3205     ISO Abbreviation:  Life Sci.     Publication Date:  1982 May 
Date Detail:
Created Date:  1982-09-24     Completed Date:  1982-09-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375521     Medline TA:  Life Sci     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1835-40     Citation Subset:  IM    
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MeSH Terms
Anti-Arrhythmia Agents*
Blood Pressure / drug effects
Cardiovascular System / drug effects*
Endorphins / antagonists & inhibitors,  pharmacology*
Heart Rate / drug effects
Medulla Oblongata / drug effects
Naloxone / pharmacology
Rats, Inbred Strains
Reg. No./Substance:
0/Anti-Arrhythmia Agents; 0/Endorphins; 465-65-6/Naloxone; 60617-12-1/beta-Endorphin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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