Document Detail


The inhibitory effects of representative chalcones contained in Angelica keiskei on melanin biosynthesis in B16 melanoma cells.
MedLine Citation:
PMID:  22978217     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
In our effort to find new whitening agents, we evaluated the effects of representative chalcones [4-hydroxyderricin (1), xanthoangelol (2), xanthoangelol H (3), deoxyxanthoangelol H (4), and deoxydihydroxanthoangelol H (5)] contained in the stem of Angelica keiskei on tyrosinase and melanin formation in B16 melanoma cells. In addition, the antioxidant effects of these chalcones in ORAC and DPPH assays were also determined. Interestingly, all chalcones (1-5) inhibit melanin formation in B16 melanoma cells, with low cytotoxicity.
Authors:
Enos Tangke Arung; Shoko Furuta; Kazuhiro Sugamoto; Kuniyoshi Shimizu; Hiroya Ishikawa; Yoh-ichi Matsushita; Ryuichiro Kondo
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Natural product communications     Volume:  7     ISSN:  1934-578X     ISO Abbreviation:  Nat Prod Commun     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-09-17     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101477873     Medline TA:  Nat Prod Commun     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1007-10     Citation Subset:  IM    
Affiliation:
Department of Forest Product Technology, Faculty of Forestry, Mulawarman University, Samarinda, 75123, Indonesia.
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