Document Detail


The inhibitory effects of interferon gamma on the growth of bladder cancer cells.
MedLine Citation:
PMID:  1569695     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The inhibitory effect of interferon-gamma on the growth of three human bladder cancer cell lines, RT4, RT112 and MGH-U1, representing tumour grades 1, 2 and 3 respectively, was studied. The effects of 10, 100 and 1000 Uml.-1 of interferon-gamma on cell numbers and thymidine incorporation were measured at 24 hour intervals up to a maximum of seven days. Morphological appearances were also studied. Each line was susceptible to the growth inhibitory effects of interferon-gamma and this was both dose and time dependent. The effects of interferon-gamma, on the RT4 and RT112 cells were apparent from 24 hours, and were both cytostatic and cytotoxic in nature, whereas the effects on MGH-U1 cells were seen from 48 hours onwards and were only cytostatic. Cytological changes occurred in all three cell lines, being most pronounced in RT112. The growth of bladder cancer cells was inhibited by interferon-gamma, and in this study high grade tumour cells were least sensitive.
Authors:
S J Hawkyard; A M Jackson; K James; S Prescott; J F Smyth; G D Chisholm
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of urology     Volume:  147     ISSN:  0022-5347     ISO Abbreviation:  J. Urol.     Publication Date:  1992 May 
Date Detail:
Created Date:  1992-05-26     Completed Date:  1992-05-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0376374     Medline TA:  J Urol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1399-403     Citation Subset:  AIM; IM    
Affiliation:
Department of Surgery/Urology, Western General Hospital, Edinburgh, United Kingdom.
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MeSH Terms
Descriptor/Qualifier:
Carcinoma, Transitional Cell / pathology*
Cell Division / drug effects*
Growth Inhibitors / pharmacology*
Humans
Interferon-gamma, Recombinant / pharmacology*
Tumor Cells, Cultured / drug effects
Urinary Bladder Neoplasms / pathology*
Chemical
Reg. No./Substance:
0/Growth Inhibitors; 0/Interferon-gamma, Recombinant

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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