| The inhibitory effects of eckol and dieckol from Ecklonia stolonifera on the expression of matrix metalloproteinase-1 in human dermal fibroblasts. | |
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MedLine Citation:
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PMID: 16880634 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In order to develop new anti-photoaging agents, we examined the inhibitory effects of 29 seaweed extracts on transcriptional activities of NF-kappaB and AP-1, and MMP-1 expression. The extracts from 3 species of Alariaceae, Eisenia bicyclis, Ecklonia cava and Ecklonia stolonifera, have showed strong inhibition of both NF-kappaB and AP-1 reporter activity, which were well correlated with their abilities to inhibit MMP-1 expression. In addition, MMP-1 expression was dramatically attenuated by treatment with eckol or dieckol which were purely isolated from E. stolonifera, indicating that these compounds are active principles to inhibit MMP-1 expression in human dermal fibroblasts. Taken together, our data demonstrate the inhibitory effect of eckol and dieckol from Ecklonia species on MMP-1 expression in human dermal fibroblasts and provide a possibility to develop as an agent for the prevention and treatment of skin aging. |
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Authors:
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Min-Jeong Joe; Su-Nam Kim; Hye-Young Choi; Woon-Seob Shin; Gab-Man Park; Dong-Won Kang; Yong Kee Kim |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Biological & pharmaceutical bulletin Volume: 29 ISSN: 0918-6158 ISO Abbreviation: Biol. Pharm. Bull. Publication Date: 2006 Aug |
Date Detail:
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Created Date: 2006-08-01 Completed Date: 2006-10-18 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9311984 Medline TA: Biol Pharm Bull Country: Japan |
Other Details:
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Languages: eng Pagination: 1735-9 Citation Subset: IM |
Affiliation:
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Marine Biomedical Research Center, Kwandong University College of Medicine, Korea. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Algae, Brown
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chemistry* Base Sequence Benzofurans / pharmacology* Blotting, Western Cells, Cultured DNA Primers Dioxins / pharmacology* Fibroblasts / drug effects, enzymology Humans Matrix Metalloproteinase 1 / genetics, metabolism* Reverse Transcriptase Polymerase Chain Reaction Skin / cytology, drug effects*, enzymology |
| Chemical | |
Reg. No./Substance:
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0/Benzofurans; 0/DNA Primers; 0/Dioxins; 0/dieckol; 88798-74-7/eckol; EC 3.4.24.7/Matrix Metalloproteinase 1 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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