Document Detail


The inhibitory effects of cholalic acid and hyodeoxycholalic acid on the expression of TNFalpha and IL-1beta after cerebral ischemia in rats.
MedLine Citation:
PMID:  19183878     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Previous studies have shown that Qing Kai Ling, a traditional Chinese medicine, was able to effectively prevent the inflammation from cerebral ischemia (Chen et al., 2002). The cholalic acid and hyodeoxycholalic acid (cholalic acid mixture) was major active components in Qing Kai Ling. To study the effects of cholalic acid mixture on the damage cascade of cerebral ischemia, rat model of focal cerebral ischemia was established by permanent occlusion of left middle cerebral artery. We found that the administration of cholalic acid mixture could reduce the ischemic infarct size after 24 h of ischemia, and cholalic acid mixture could be detected in cerebrospinal fluid after 2h of administration. We also found that the concentrations of tumor necrosis factor-alpha and interlukin-1beta in rat brain were significantly lower when compared to the untreated animals after 12 h and 24 h of ischemia. The concentrations of von Willebrand factor and neuron specific enolase in the plasma were remarkably decreased in cholalic acid mixture treated animals than in the untreated ones after 12h of ischemia. Our results suggested that cholalic acid mixture is able to decrease the expression of inflammation factors including tumor necrosis factor-alpha and interlukin-1beta after focal cerebral ischemia.
Authors:
Qian Hua; Xiao-Lei Zhu; Peng-Tao Li; Yuan Liu; Na Zhang; Ya Xu; Xu Jia
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-01-29
Journal Detail:
Title:  Archives of pharmacal research     Volume:  32     ISSN:  0253-6269     ISO Abbreviation:  Arch. Pharm. Res.     Publication Date:  2009 Jan 
Date Detail:
Created Date:  2009-02-02     Completed Date:  2009-02-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8000036     Medline TA:  Arch Pharm Res     Country:  Korea (South)    
Other Details:
Languages:  eng     Pagination:  65-73     Citation Subset:  IM    
Affiliation:
School of Preclinical Medicine, Beijing University of Chinese Medicine, Chaoyang District, Beijing, 100029, China.
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MeSH Terms
Descriptor/Qualifier:
Animals
Anti-Inflammatory Agents / pharmacology*
Brain / drug effects*,  immunology,  pathology
Cholic Acids / pharmacology*
Deoxycholic Acid / pharmacology*
Disease Models, Animal
Down-Regulation
Infarction, Middle Cerebral Artery / drug therapy*,  immunology,  pathology
Interleukin-1beta / metabolism*
Phosphopyruvate Hydratase / metabolism
Rats
Rats, Sprague-Dawley
Time Factors
Tumor Necrosis Factor-alpha / metabolism*
von Willebrand Factor / metabolism
Chemical
Reg. No./Substance:
0/Anti-Inflammatory Agents; 0/Cholic Acids; 0/Interleukin-1beta; 0/Tumor Necrosis Factor-alpha; 0/von Willebrand Factor; 83-44-3/Deoxycholic Acid; 83-49-8/hyodeoxycholic acid; EC 4.2.1.11/Phosphopyruvate Hydratase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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