| The inhibitory effects on adult male reproductive functions of crude garlic (Allium sativum) feeding. | |
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MedLine Citation:
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PMID: 18097508 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIM: to investigate the effects of crude garlic on adult male rat reproductive functions. METHODS: Thirty male rats were divided into five groups: group 1 (untreated) and groups 2, 3, 4 and 5 were fed for 30 days with 5%, 10%, 15% and 30% crude garlic, respectively. Testes and accessory organs were weighed and some markers were assessed. Light and electron microscopy observations were also performed. RESULTS: A significant decrease was observed in the body weight of groups 4 (14%; P < 0.01) and 5 (20%; P < 0.01); of the prostate weight in group 5 (29.1%; P < 0.05) and of seminal vesicle weight in groups 3 (14.4%; P < 0.01), 4 (18.3%; P < 0.01) and 5 (27.3%; P < 0.01). In contrast, testis and epididymis weights were unchanged. In epididymis tissue, the alpha glucosidase activity and the spermatozoa density were unchanged. The treatment resulted in a significant decrease in testosterone serum levels in groups 3 (77.3%; P < 0.01), 4 (77.3%; P < 0.01) and 5 (90.9%; P < 0.01), associated with a significant increase in LH serum levels (P < 0.01). Testicular histology showed a dose-dependent increase in the percentage of empty seminiferous tubules. Moreover, testicular function was affected; a significant decrease in phosphatase acid activity (P < 0.01) and testosterone (P < 0.05) contents were observed. CONCLUSION: Crude garlic consumption during 1 month reduced testosterone secretion and altered spermatogenesis at 10%, 15% and 30% doses. |
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Authors:
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Imen Hammami; Afef Nahdi; Claire Mauduit; Mohamed Benahmed; Mohamed Amri; Awatef Ben Amar; Semy Zekri; Ahmed El May; Michele Veronique El May |
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Publication Detail:
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Type: Journal Article Date: 2007-12-20 |
Journal Detail:
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Title: Asian journal of andrology Volume: 10 ISSN: 1008-682X ISO Abbreviation: Asian J. Androl. Publication Date: 2008 Jul |
Date Detail:
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Created Date: 2008-05-14 Completed Date: 2008-07-29 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100942132 Medline TA: Asian J Androl Country: China |
Other Details:
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Languages: eng Pagination: 593-601 Citation Subset: IM |
Affiliation:
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Research Unity 01/UR/08-07, Faculty of Medicine, Tunis, Tunisia. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Dose-Response Relationship, Drug Epididymis / drug effects, physiology Garlic / adverse effects* Leydig Cells / drug effects, physiology Luteinizing Hormone / blood Male Plant Preparations / pharmacology* Prostate / drug effects, physiology Rats Rats, Wistar Reproduction / drug effects, physiology* Seminal Vesicles / drug effects, physiology Sertoli Cells / drug effects, physiology Sperm Count Spermatogenesis / drug effects, physiology Testis / cytology, drug effects*, metabolism Testosterone / blood |
| Chemical | |
Reg. No./Substance:
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0/Plant Preparations; 58-22-0/Testosterone; 9002-67-9/Luteinizing Hormone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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