Document Detail


The inhibitory effects of Radix Astragali on hypoxic pulmonary hypertension of rats.
MedLine Citation:
PMID:  11189248     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To observe the inhibitory effects of Radix Astragali (RA) on hypoxic structural remodeling of intraacinar pulmonary arteries (IAPA) and pulmonary hypertension (PHT). METHODS: Sixty rats were divided into three groups: hypoxia group, hypoxia + RA group and normal control group. The rats of hypoxia group and hypoxia + RA group were fed in hypoxic environment under normal atmospheric pressure (10% O2, 10 h/day). On the 15th and 30th day of hypoxia, right ventricular systolic pressure (RVSP) and right ventricle hypertrophy index (RVHI) were measured and pulmonary vessel changes were studied under light and electron microscope and with morphometric analysis. RESULTS: Compared with the result of hypoxia + RA group, RA could relieve IAPA wall cell injuries and dilate the constricted IAPA induced by hypoxia. RA could also inhibit hypertrophic changes in the tunica media and proliferation of adventitial cells of the IAPA and muscularization of nonmuscular arteries. CONCLUSION: By preserving the IAPA wall cells and dilating IAPA, RA may play an important role in inhibiting the remodeling of IAPA and preventing PHT.
Authors:
S Xi; Y Ruan; Y Liu; L Zhang; W Si
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Chinese medical journal     Volume:  111     ISSN:  0366-6999     ISO Abbreviation:  Chin. Med. J.     Publication Date:  1998 Oct 
Date Detail:
Created Date:  2001-01-12     Completed Date:  2001-03-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7513795     Medline TA:  Chin Med J (Engl)     Country:  China    
Other Details:
Languages:  eng     Pagination:  956-8     Citation Subset:  IM    
Affiliation:
Department of Pathology, Cardiovascular Institute and Fuwai Hospital, Chinese Academy of Medical Sciences, Beijing 100037, China.
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MeSH Terms
Descriptor/Qualifier:
Animals
Anoxia / complications*
Drugs, Chinese Herbal / pharmacology*
Fabaceae*
Hypertension, Pulmonary / physiopathology,  prevention & control*
Plants, Medicinal*
Pulmonary Artery / pathology
Random Allocation
Rats
Rats, Wistar
Chemical
Reg. No./Substance:
0/Drugs, Chinese Herbal

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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