| The inhibitory effects of Radix Astragali on hypoxic pulmonary hypertension of rats. | |
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MedLine Citation:
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PMID: 11189248 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To observe the inhibitory effects of Radix Astragali (RA) on hypoxic structural remodeling of intraacinar pulmonary arteries (IAPA) and pulmonary hypertension (PHT). METHODS: Sixty rats were divided into three groups: hypoxia group, hypoxia + RA group and normal control group. The rats of hypoxia group and hypoxia + RA group were fed in hypoxic environment under normal atmospheric pressure (10% O2, 10 h/day). On the 15th and 30th day of hypoxia, right ventricular systolic pressure (RVSP) and right ventricle hypertrophy index (RVHI) were measured and pulmonary vessel changes were studied under light and electron microscope and with morphometric analysis. RESULTS: Compared with the result of hypoxia + RA group, RA could relieve IAPA wall cell injuries and dilate the constricted IAPA induced by hypoxia. RA could also inhibit hypertrophic changes in the tunica media and proliferation of adventitial cells of the IAPA and muscularization of nonmuscular arteries. CONCLUSION: By preserving the IAPA wall cells and dilating IAPA, RA may play an important role in inhibiting the remodeling of IAPA and preventing PHT. |
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Authors:
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S Xi; Y Ruan; Y Liu; L Zhang; W Si |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Chinese medical journal Volume: 111 ISSN: 0366-6999 ISO Abbreviation: Chin. Med. J. Publication Date: 1998 Oct |
Date Detail:
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Created Date: 2001-01-12 Completed Date: 2001-03-01 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7513795 Medline TA: Chin Med J (Engl) Country: China |
Other Details:
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Languages: eng Pagination: 956-8 Citation Subset: IM |
Affiliation:
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Department of Pathology, Cardiovascular Institute and Fuwai Hospital, Chinese Academy of Medical Sciences, Beijing 100037, China. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anoxia / complications* Drugs, Chinese Herbal / pharmacology* Fabaceae* Hypertension, Pulmonary / physiopathology, prevention & control* Plants, Medicinal* Pulmonary Artery / pathology Random Allocation Rats Rats, Wistar |
| Chemical | |
Reg. No./Substance:
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0/Drugs, Chinese Herbal |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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