| The inhibitory effect of statins on urinary 11-dehydrothromboxane levels. | |
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MedLine Citation:
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PMID: 20502413 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIM: Elevated urinary 11-dehydrothromboxane levels place patients at an increased risk for experiencing cardiovascular events. Statins exert an inhibitory effect on platelets. The aim of our study was to determine the effect of 3-month statin therapy on 11-dehydrothromboxane elimination in two groups of patients, one not receiving antiplatelet therapy with acetylsalicylic acid and the other receiving 100 mg acetylsalicylic acid per day. METHODS: We examined the urinary levels of 11-dehydrothromboxane in a total of 58 patients before and after 3-month therapy with a statin at standard doses (simvastatin, fluvastatin, atorvastatin). We also examined the plasma levels of total cholesterol, triglycerides, LDL- and HDL-cholesterol, C-reactive protein, and blood glucose. RESULTS: After 3-month statin therapy, both groups of patients (with and without antiplatelet therapy) showed a significant decrease in urinary 11-dehydrothromboxane levels. Significant decreases were also seen in LDL- and total cholesterol, and C-reactive protein. Changes in the other parameters were not significant. CONCLUSION: Three-month statin therapy significant reduces the rate of 11-dehydrothromboxane elimination, even in patients on acetylsalicylic acid. In addition to its usual lipid-lowering effect, it significantly decreases the plasma levels of C-reactive protein. Combination therapy with a statin plus acetylsalicylic acid may be effective even in patients with incomplete thromboxane inhibition on antiplatelet therapy with acetylsalicylic acid. |
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Authors:
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S Alusik; Z Paluch; M Lejsková; T Adámek |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: International angiology : a journal of the International Union of Angiology Volume: 29 ISSN: 1827-1839 ISO Abbreviation: Int Angiol Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-05-26 Completed Date: 2010-09-03 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8402693 Medline TA: Int Angiol Country: Italy |
Other Details:
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Languages: eng Pagination: 255-9 Citation Subset: IM |
Affiliation:
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Department of Medicine I, Thomayer University Hospital, Prague, Czech Republic. stefan.alusik@ftn.cz |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aspirin / therapeutic use Biological Markers / blood, urine Blood Glucose / metabolism Blood Platelets / drug effects*, metabolism C-Reactive Protein / metabolism Cholesterol, HDL / blood Cholesterol, LDL / blood Czech Republic Down-Regulation Fatty Acids, Monounsaturated / therapeutic use Female Heptanoic Acids / therapeutic use Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors / therapeutic use* Indoles / therapeutic use Male Middle Aged Platelet Aggregation Inhibitors / therapeutic use Pyrroles / therapeutic use Simvastatin / therapeutic use Thromboxane B2 / analogs & derivatives*, urine Time Factors Treatment Outcome Triglycerides / blood |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Blood Glucose; 0/Cholesterol, HDL; 0/Cholesterol, LDL; 0/Fatty Acids, Monounsaturated; 0/Heptanoic Acids; 0/Hydroxymethylglutaryl-CoA Reductase Inhibitors; 0/Indoles; 0/Platelet Aggregation Inhibitors; 0/Pyrroles; 0/Triglycerides; 110862-48-1/atorvastatin; 50-78-2/Aspirin; 54397-85-2/Thromboxane B2; 67910-12-7/11-dehydro-thromboxane B2; 79902-63-9/Simvastatin; 9007-41-4/C-Reactive Protein; 93957-54-1/fluvastatin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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