Document Detail


The inhibitory effect of heparin on trypsinogen activation with enterokinase.
MedLine Citation:
PMID:  930538     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effect of heparin on the activation of trypsinogen by enterokinase and on trypsin activity has been investigated. Proteolytic activity of trypsin has been determined using caseinolytic method. It has been found that heparin inhibits trypsinogen activation only when it is preincubated with proenzyme before introduction of enterokinase to the tested system. In these experimental conditions heparin in final concentrations from 1 to 20 U/ml exhibits inhibitory effect diminishing trypsinogen activation to about 65% initial activity and in higher concentrations only to 50%. Heparin introduced to the tested system simultaneously with enterokinase or to the active trypsin did not appear evident inhibitory effect.
Authors:
N Wolosowicz; J Prokopowicz; A Gabryelewicz
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta hepato-gastroenterologica     Volume:  24     ISSN:  0300-970X     ISO Abbreviation:  Acta Hepatogastroenterol (Stuttg)     Publication Date:  1977 Oct 
Date Detail:
Created Date:  1978-01-27     Completed Date:  1978-01-27     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0340734     Medline TA:  Acta Hepatogastroenterol (Stuttg)     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  368-71     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Endopeptidases / pharmacology*
Enteropeptidase / pharmacology*
Enzyme Activation / drug effects
Enzyme Inhibitors*
Enzyme Precursors
Heparin / pharmacology*
Humans
Trypsinogen / antagonists & inhibitors*
Chemical
Reg. No./Substance:
0/Enzyme Inhibitors; 0/Enzyme Precursors; 9002-08-8/Trypsinogen; 9005-49-6/Heparin; EC 3.4.-/Endopeptidases; EC 3.4.21.9/Enteropeptidase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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