Document Detail


The inhibitory effect of ginseng pectin on L-929 cell migration.
MedLine Citation:
PMID:  20512465     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We tested the effects of ginseng pectin prepared by enzymatic hydrolysis of ginseng polysaccharides on cell migration. Ginseng pectin impaired the migration of L-929 cells and reduced their migration speed by up to 50% of control in the presence or absence of serum, suggesting it worked on both serum-dependent and serum-independent migration pathways. Ginseng pectin impaired cell migration via decreased cell spreading. These findings represent a significant contribution towards understanding the bioactivities of ginseng polysaccharides and applying them to health food and medicine.
Authors:
Yuying Fan; Hairong Cheng; Dan Liu; Xu Zhang; Bo Wang; Lin Sun; Guihua Tai; Yifa Zhou
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-05-29
Journal Detail:
Title:  Archives of pharmacal research     Volume:  33     ISSN:  0253-6269     ISO Abbreviation:  Arch. Pharm. Res.     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-05-31     Completed Date:  2010-09-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8000036     Medline TA:  Arch Pharm Res     Country:  Korea (South)    
Other Details:
Languages:  eng     Pagination:  681-9     Citation Subset:  IM    
Affiliation:
Northeast Normal University, Changchun, Jilin Province, China.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Line
Cell Line, Tumor
Cell Movement / drug effects*
Dose-Response Relationship, Drug
Drug Evaluation, Preclinical / methods
Humans
Hydrolysis
Panax / chemistry*
Pectins / chemical synthesis,  pharmacology*
Polysaccharides / chemistry
Chemical
Reg. No./Substance:
0/Pectins; 0/Polysaccharides; 9000-69-5/pectin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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