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The inhibition of pulmonary vessel remodeling by carbon monoxide system in rats with chronic pulmonary heart disease.
MedLine Citation:
PMID:  12435299     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
OBJECTIVE: To study the effect of carbon monoxide on pulmonary vessel remodeling of chronic pulmonary heart disease.
METHODS: Thirty-six sprague-dawley rats were randomly divided into three groups: control group, and hypoxic hypercapnic group, and hypoxic hypercapnia + hemin group. Blood CO concentration (COHb%), activity of HO-1 in blood serum and lung homogenate, pulmonary arteriole micromorphometric index, HO-1 and HO-1 mRNA were measured.
RESULTS: (1) mPAP and RV/(LV + S) were (20.1 +/- 0.8) mm Hg and (35.5 +/- 1.7)% in hypoxic hypercapnic group, they were significantly higher than those of control group's (15.3 +/- 1.4) mm Hg, (26.7 +/- 1.7)%, and those of hypoxic hypercapnia + hemin (activator of HO-1) group's (16.5 +/- 3.7) mm Hg, (30.2 +/- 1.6)% (P < 0.01). (2) Pulmonary arteriole micromorphometric index in rats of hypoxic hypercapnic group were significantly higher than those of control group and hypoxic hypercapnia + hemin group (P < 0.01). (3) Blood CO concentration, activity of HO-1 in blood serum and lung homogenate, content of HO-1 and HO-1 mRNA in pulmonary arterioles in rats of hypoxic hypercapnic group were (2.1 +/- 0.9)%, (73 +/- 18) nmol.L(-1).h(-1), (1 751 +/- 311) pmol.mg(-1).h(-1), 0.191 +/- 0.012 and 0.301 +/- 0.017, were significantly higher than those of control group: (0.5 +/- 0.3)%, (25 +/- 8) nmol.L(-1).h(-1), (385 +/- 46) pmol.mg(-1).h(-1), 0.059 +/- 0.005, 0.131 +/- 0.011, but were significantly lower than those of hypoxic hypercapnia + hemin group: (4.9 +/- 2.1)%, (132 +/- 39) nmol.L(-1).h(-1), (2 849 +/- 426) pmol.mg(-1).h(-1), 0.272 +/- 0.013, 0.339 +/- 0.020 (P < 0.01). (4) Correlation analysis revealed that the relationship between carbon monoxide system and pulmonary arteriole micromorphometric index was significantly negative (P < 0.01).
CONCLUSION: Up-regulation of endogenous carbon monoxide system can inhibit pulmonary vessel remodeling in rats with chronic pulmonary heart disease induced by hypoxia and hypercapnia.
Authors:
Xiaoying Huang; Liangxing Wang; Shaoxian Chen; Zhengjie Xu; Qunji Wang; Xiaofang Fan
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases     Volume:  25     ISSN:  1001-0939     ISO Abbreviation:  Zhonghua Jie He He Hu Xi Za Zhi     Publication Date:  2002 Jul 
Date Detail:
Created Date:  2002-11-18     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8712226     Medline TA:  Zhonghua Jie He He Hu Xi Za Zhi     Country:  China    
Other Details:
Languages:  eng     Pagination:  408-11     Citation Subset:  IM    
Affiliation:
Department of Respirology First Hospital, Institute of Cor Pulmonale, Wenzhou Medical College, Wenzhou 325003, China.
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