Document Detail

The inhibition of pro-inflammatory cytokines with pentoxifylline in the cardiopulmunary bypass lung.
MedLine Citation:
PMID:  12000008     Owner:  NLM     Status:  MEDLINE    
In addition to preventing tissue energy loss during cardiopulmonary bypass, pentoxifylline (Ptx) prevents the production of pro-inflammatory cytokines as well. The aim of this study was to investigate whether Ptx decreases the inflammatory effects of cardiopulmonary bypass on the lungs during open-heart surgery. The patients in the study group (n = 15) who were going through an open-heart surgery had 500 mg l(-1) of Ptx added to their prime solution, whereas the patients in the control group (n = 10) only received prime solution. Pre-pump and post-pump blood samples were obtained from both groups and assayed for interleukin-6 (IL-6), interleukin-8 (IL-8) and tumour necrosis factor alpha (TNFalpha). Lung tissue samples that were obtained after the pump were examined with light microscopy and stained for tissueTNFalpha. Non-parametric Wilcoxon test was utilized for statistical evaluation. In the post-pump period, the difference in the IL-6, IL-8 and TNFalpha levels of the two groups was found to be statistically significant (P<0.005). The tissue samples from the control group had significant staining with TNFalpha. We think that Ptx has important protective effects on the lungs during cardiopulmonary bypass.
H Ustünsoy; M C Sivrikoz; K Bakir; Senkaya; B Erbagci; R Uçak; F Nurözler
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  Respiratory medicine     Volume:  96     ISSN:  0954-6111     ISO Abbreviation:  Respir Med     Publication Date:  2002 Apr 
Date Detail:
Created Date:  2002-05-09     Completed Date:  2002-06-03     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8908438     Medline TA:  Respir Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  275-9     Citation Subset:  IM    
Department of Cardiovascular and Thorax Surgery, Gaziantep University School of Medicine, Turkey.
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MeSH Terms
Cardiopulmonary Bypass*
Cytokines / antagonists & inhibitors*
Double-Blind Method
Enzyme Inhibitors / therapeutic use*
Heart Atria
Interleukin-6 / blood
Interleukin-8 / blood
Intraoperative Period
Lung / drug effects*,  immunology
Pentoxifylline / therapeutic use*
Tumor Necrosis Factor-alpha / analysis
Reg. No./Substance:
0/Cytokines; 0/Enzyme Inhibitors; 0/Interleukin-6; 0/Interleukin-8; 0/Tumor Necrosis Factor-alpha; 6493-05-6/Pentoxifylline

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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