| The inhibition of pro-inflammatory cytokines with pentoxifylline in the cardiopulmunary bypass lung. | |
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MedLine Citation:
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PMID: 12000008 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In addition to preventing tissue energy loss during cardiopulmonary bypass, pentoxifylline (Ptx) prevents the production of pro-inflammatory cytokines as well. The aim of this study was to investigate whether Ptx decreases the inflammatory effects of cardiopulmonary bypass on the lungs during open-heart surgery. The patients in the study group (n = 15) who were going through an open-heart surgery had 500 mg l(-1) of Ptx added to their prime solution, whereas the patients in the control group (n = 10) only received prime solution. Pre-pump and post-pump blood samples were obtained from both groups and assayed for interleukin-6 (IL-6), interleukin-8 (IL-8) and tumour necrosis factor alpha (TNFalpha). Lung tissue samples that were obtained after the pump were examined with light microscopy and stained for tissueTNFalpha. Non-parametric Wilcoxon test was utilized for statistical evaluation. In the post-pump period, the difference in the IL-6, IL-8 and TNFalpha levels of the two groups was found to be statistically significant (P<0.005). The tissue samples from the control group had significant staining with TNFalpha. We think that Ptx has important protective effects on the lungs during cardiopulmonary bypass. |
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Authors:
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H Ustünsoy; M C Sivrikoz; K Bakir; Senkaya; B Erbagci; R Uçak; F Nurözler |
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Publication Detail:
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Type: Clinical Trial; Controlled Clinical Trial; Journal Article |
Journal Detail:
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Title: Respiratory medicine Volume: 96 ISSN: 0954-6111 ISO Abbreviation: Respir Med Publication Date: 2002 Apr |
Date Detail:
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Created Date: 2002-05-09 Completed Date: 2002-06-03 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8908438 Medline TA: Respir Med Country: England |
Other Details:
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Languages: eng Pagination: 275-9 Citation Subset: IM |
Affiliation:
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Department of Cardiovascular and Thorax Surgery, Gaziantep University School of Medicine, Turkey. hustunsoy@yahoo.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Cardiopulmonary Bypass* Cytokines / antagonists & inhibitors* Double-Blind Method Enzyme Inhibitors / therapeutic use* Female Heart Atria Humans Immunohistochemistry Interleukin-6 / blood Interleukin-8 / blood Intraoperative Period Lung / drug effects*, immunology Male Pentoxifylline / therapeutic use* Tumor Necrosis Factor-alpha / analysis |
| Chemical | |
Reg. No./Substance:
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0/Cytokines; 0/Enzyme Inhibitors; 0/Interleukin-6; 0/Interleukin-8; 0/Tumor Necrosis Factor-alpha; 6493-05-6/Pentoxifylline |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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