Document Detail

Müllerian-inhibiting substance function during mammalian sexual development.
MedLine Citation:
PMID:  7954809     Owner:  NLM     Status:  MEDLINE    
To investigate the role of Müllerian-inhibiting substance (MIS) in mammalian sexual development, we generated MIS-deficient mice. Although MIS-deficient males had testes that were fully descended and produced functional sperm, they also developed female reproductive organs, which interfered with sperm transfer into females, rendering most of these males infertile. Their testes had Leydig cell hyperplasia and, in one instance, neoplasia. The actions of the two primary hormones of male sexual differentiation were genetically eliminated using the testicular feminization (Tfm) mutation in combination with the MIS mutant allele. XY Tfm/MIS double mutants developed as females, with a uterus, coiled oviducts, and no male reproductive organs except undescended dysfunctional testes. These results suggest that eliminating the presumptive female reproductive tract in male fetuses facilitates fertility and that in testes MIS is a negative regulator of Leydig cell proliferation. Eliminating the presumptive male reproductive tract is necessary for proper oviductal morphogenesis during female mouse development.
R R Behringer; M J Finegold; R L Cate
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Cell     Volume:  79     ISSN:  0092-8674     ISO Abbreviation:  Cell     Publication Date:  1994 Nov 
Date Detail:
Created Date:  1994-12-20     Completed Date:  1994-12-20     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0413066     Medline TA:  Cell     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  415-25     Citation Subset:  IM    
Department of Molecular Genetics, University of Texas, M. D. Anderson Cancer Center, Houston 77030.
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MeSH Terms
Androgen-Insensitivity Syndrome / embryology
Anti-Mullerian Hormone
Cell Division
Fertility / physiology
Genitalia, Male / anatomy & histology,  embryology*
Growth Inhibitors / genetics,  physiology*
Leydig Cells / physiology
Mice, Knockout
Mullerian Ducts / embryology*
Oviducts / growth & development
Pseudohermaphroditism / genetics,  pathology
Sex Differentiation / physiology*
Testicular Hormones / genetics,  physiology*
Testis / pathology
Wolffian Ducts / embryology
Grant Support
Reg. No./Substance:
0/Glycoproteins; 0/Growth Inhibitors; 0/Testicular Hormones; 80497-65-0/Anti-Mullerian Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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