Document Detail

An inherited functional circadian clock in zebrafish embryos.
MedLine Citation:
PMID:  10894777     Owner:  NLM     Status:  MEDLINE    
Circadian clocks are time-keeping systems found in most organisms. In zebrafish, expression of the clock gene Period3 (Per3) oscillates throughout embryogenesis in the central nervous system and the retina. Per3 rhythmic expression was free-running and was reset by light but not by the developmental delays caused by low temperature. The time of fertilization had no effect on Per3 expression. Per3 messenger RNA accumulates rhythmically in oocytes and persists in embryos. Our results establish that the circadian clock functions during early embryogenesis in zebrafish. Inheritance of maternal clock gene products suggests a mechanism of phase inheritance through ovogenesis.
F Delaunay; C Thisse; O Marchand; V Laudet; B Thisse
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Science (New York, N.Y.)     Volume:  289     ISSN:  0036-8075     ISO Abbreviation:  Science     Publication Date:  2000 Jul 
Date Detail:
Created Date:  2000-07-25     Completed Date:  2000-07-25     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0404511     Medline TA:  Science     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  297-300     Citation Subset:  IM    
Ecole Normale Supérieure, CNRS UMR 5665, 46 allée d'Italie, 69364 Lyon Cedex, France.
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MeSH Terms
Amino Acid Sequence
Circadian Rhythm* / genetics
DNA-Binding Proteins*
Embryo, Nonmammalian / metabolism
Embryonic Development
Gene Expression Regulation, Developmental
Molecular Sequence Data
Nuclear Proteins / genetics*,  physiology
Period Circadian Proteins
Proteins / genetics
Receptors, Cytoplasmic and Nuclear*
Transcription Factors
Zebrafish / embryology,  physiology*
Reg. No./Substance:
0/DNA-Binding Proteins; 0/Nuclear Proteins; 0/Period Circadian Proteins; 0/Proteins; 0/Receptors, Cytoplasmic and Nuclear; 0/Transcription Factors; 0/per3 protein, zebrafish

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