Document Detail


The inheritance of high density lipoprotein cholesterol and apolipoproteins A-I and A-II.
MedLine Citation:
PMID:  6426485     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A large pedigree was ascertained through cases of early myocardial infarction. High density lipoprotein cholesterol and apolipoproteins A-I and A-II were measured on family members. Likelihood analysis, using the polygenic/major gene mixed model, provided no evidence that major loci play a role in determining the levels of any of the three measurements. Heritability estimates, assuming polygenic inheritance, were 0.59 and 0.26 for HDL-C level and A-II level, respectively. No evidence of genetic transmission of A-I level was found.
Authors:
S J Hasstedt; J J Albers; M C Cheung; L B Jorde; D E Wilson; C Q Edwards; W N Cannon; K O Ash; R R Williams
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Atherosclerosis     Volume:  51     ISSN:  0021-9150     ISO Abbreviation:  Atherosclerosis     Publication Date:  1984 Apr 
Date Detail:
Created Date:  1984-06-21     Completed Date:  1984-06-21     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0242543     Medline TA:  Atherosclerosis     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  21-9     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Apolipoprotein A-I
Apolipoprotein A-II
Apolipoproteins / blood,  genetics*
Cholesterol / blood,  genetics*
Cholesterol, HDL
Female
Humans
Lipoproteins, HDL / blood,  genetics*
Male
Middle Aged
Myocardial Infarction / blood,  genetics
Pedigree
Risk
Grant Support
ID/Acronym/Agency:
HL-21088-06/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Apolipoprotein A-I; 0/Apolipoprotein A-II; 0/Apolipoproteins; 0/Cholesterol, HDL; 0/Lipoproteins, HDL; 57-88-5/Cholesterol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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