| The inheritance of high density lipoprotein cholesterol and apolipoproteins A-I and A-II. | |
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MedLine Citation:
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PMID: 6426485 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A large pedigree was ascertained through cases of early myocardial infarction. High density lipoprotein cholesterol and apolipoproteins A-I and A-II were measured on family members. Likelihood analysis, using the polygenic/major gene mixed model, provided no evidence that major loci play a role in determining the levels of any of the three measurements. Heritability estimates, assuming polygenic inheritance, were 0.59 and 0.26 for HDL-C level and A-II level, respectively. No evidence of genetic transmission of A-I level was found. |
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Authors:
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S J Hasstedt; J J Albers; M C Cheung; L B Jorde; D E Wilson; C Q Edwards; W N Cannon; K O Ash; R R Williams |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Atherosclerosis Volume: 51 ISSN: 0021-9150 ISO Abbreviation: Atherosclerosis Publication Date: 1984 Apr |
Date Detail:
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Created Date: 1984-06-21 Completed Date: 1984-06-21 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0242543 Medline TA: Atherosclerosis Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 21-9 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Apolipoprotein A-I Apolipoprotein A-II Apolipoproteins / blood, genetics* Cholesterol / blood, genetics* Cholesterol, HDL Female Humans Lipoproteins, HDL / blood, genetics* Male Middle Aged Myocardial Infarction / blood, genetics Pedigree Risk |
| Grant Support | |
ID/Acronym/Agency:
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HL-21088-06/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Apolipoprotein A-I; 0/Apolipoprotein A-II; 0/Apolipoproteins; 0/Cholesterol, HDL; 0/Lipoproteins, HDL; 57-88-5/Cholesterol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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