| The inheritance of MS susceptibility. | |
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MedLine Citation:
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PMID: 2190946 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The object of this study was to determine, if possible, the mode of inheritance of the susceptibility to multiple sclerosis (MS). It was known that no single-gene model could fit the observations, so oligogenic models (models involving a small number of genes) were sought. Oligogenic hypotheses were tested against the available population data for MS until a reasonable level of agreement was found. The best-fitting simple hypothesis was this: MS occurs only in people who are homozygous for a recessive gene and carry a dominant X gene, and then only with reduced penetrance. The dangerous allele m- at the autosomal locus appears to be fairly uniformly distributed across England, Ireland and Canada, occurring in 10-30% of the gene pool. There are large variations in the frequency of the allele s- at the X-locus, ranging from 10% up to 72% of the gene pool. The penetrance varies significantly with geographical location, but nowhere approaches unity, so that the environmental factors are of great importance. The hypothesis explains the broad features of the population pattern of the occurrence of MS and it gives an outstanding fit to the best available data on MS in relatives. The result may assist attempts to map the genetic data on MS, opens the way for a reassessment of the attempts to identify the environmental factors, and it makes possible the completion of nonempirical risk tables for various countries. Similar techniques may be applied to other disorders with a genetic component in their aetiology. |
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Authors:
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D Lord; A G O'Farrell; H Staunton; E Keelan |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Irish journal of medical science Volume: 159 Suppl 8 ISSN: 0021-1265 ISO Abbreviation: Ir J Med Sci Publication Date: 1990 Jan |
Date Detail:
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Created Date: 1990-07-16 Completed Date: 1990-07-16 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 7806864 Medline TA: Ir J Med Sci Country: IRELAND |
Other Details:
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Languages: eng Pagination: 1-20 Citation Subset: IM |
Affiliation:
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Maynooth College, Co. Kildare, Ireland. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Disease Susceptibility Female Humans Male Models, Genetic Multiple Sclerosis / genetics* Risk Factors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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