Document Detail

The infusion of catecholamines in dogs under general anaesthesia with fentanyl. The effects on intrapulmonary shunt.
MedLine Citation:
PMID:  6291119     Owner:  NLM     Status:  MEDLINE    
The pulmonary venous admixture, PaO2, and pulmonary and systemic haemodynamics were studied in six mongrel dogs during infusion of dobutamine (infusion rate 7.5 micrograms . kg-1 . min-1), dopamine (7.5 micrograms . kg-1 . min-1) and isoproterenol (0.1 microgram . kg-1 . min-1). Anaesthesia was performed by a single injection of Fentanyl (0.35 mg/kg). The carbon dioxide tension and body temperature were strictly maintained within limits. Only isoproterenol produced a significant change in pulmonary arterial pressure from an average of 1.2 +/- 0.4 kPa to 1.6 +/- 0.2 kPa (P less 0.05). There was no significant change in systemic haemodynamics with any of the three drugs. The use of catecholamines in dogs with healthy lungs does not induce any development in pulmonary venous admixture when haemodynamics are unchanged. Changes in these variables are dependent upon changes in pulmonary blood flow rather than being direct effects of the catecholamine.
C D Martin; J Fabre; F Gouin; C Pomane; C Colavolpe; G François
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Resuscitation     Volume:  10     ISSN:  0300-9572     ISO Abbreviation:  Resuscitation     Publication Date:  1982 Mar 
Date Detail:
Created Date:  1982-12-16     Completed Date:  1982-12-16     Revised Date:  2009-08-25    
Medline Journal Info:
Nlm Unique ID:  0332173     Medline TA:  Resuscitation     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  63-72     Citation Subset:  IM    
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MeSH Terms
Anesthesia, General
Arteriovenous Anastomosis / drug effects
Carbon Dioxide / analysis
Catecholamines / pharmacology*
Dobutamine / pharmacology*
Dopamine / pharmacology*
Hemodynamics / drug effects
Isoproterenol / pharmacology*
Oxygen / blood
Partial Pressure
Pulmonary Alveoli / analysis
Pulmonary Circulation / drug effects*
Reg. No./Substance:
0/Anesthetics; 0/Catecholamines; 124-38-9/Carbon Dioxide; 34368-04-2/Dobutamine; 437-38-7/Fentanyl; 7683-59-2/Isoproterenol; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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